Results 51 to 60 of about 208,174 (208)

Fecal calprotectin in first-degree relatives of patients with ulcerative colitis

, 2007
OBJECTIVES: The pathogenesis of inflammatory bowel disease seems to depend on the combination of genetic and environmental factors. To evaluate genetic susceptibility, one approach is to search for specific markers in apparently unaffected family ...
Ancarani, Francesca, Montalto, Massimo, Cammarota, Giovanni, Gasbarrini, Antonio, Covino, Marcello, Gasbarrini, Giovanni Battista, Armuzzi, Alessandro, Manna, Raffaele, Santoro, Luca, Curigliano, Valentina   +9 more
core   +1 more source

Gene Polymorphisms in FAS (Rs3740286 and Rs4064) Are Involved in Endometriosis Development in Brazilian Women, but not those in CASP8 (rs13416436 and rs2037815) [PDF]

Revista Brasileira de Ginecologia e Obstetrícia, 2018
Objective The present study aims to investigate the association between caspase-8 (CASP8) (rs13416436 and rs2037815) and Fas cell surface death receptor (FAS) (rs3740286 and rs4064) polymorphisms with endometriosis in Brazilian women.
Cristina Wide Pissetti, Sarah Cristina Sato Vaz Tanaka, Andrezza Cristina Cancian Hortolani, Alessandra Bernadete Trovó de Marqui   +3 more
doaj   +1 more source

How do index patients participating in genetic screening programmes for familial hypercholesterolemia (FH) interpret their DNA results?:A UK-based qualitative interview study

, 2011
OBJECTIVE: To explore patients' interpretations of their DNA results for familial hypercholesterolemia (FH). METHODS: In-depth interviews were conducted with patients from two lipid clinics in Scotland, who were offered genetic testing as part of a ...
Jenkins, Nick, Lawton, Julia, Douglas, Margaret, Walker, Simon, Hallowell, Nina, Finnie, Robert, Porteous, Mary   +6 more
core   +1 more source

Genetic Disorders with Predisposition to Paediatric Haematopoietic Malignancies—A Review

, 2022
SIMPLE SUMMARY: A significant progress in understanding the genetic basis of childhood cancers has been made over the past years. Genome sequencing has identified significant differences between paediatric and adult cancers.
Filipiuk, Aleksandra, Lejman, Monika, Kozakiewicz, Agata, Kośmider, Kamil, Zawitkowska, Joanna, Agata Kozakiewicz, Aleksandra Filipiuk, Kamil Kośmider, Monika Lejman, Joanna Zawitkowska   +9 more
core   +1 more source

Genetic Risk Profiles for Atherosclerosis and Venous Thromboembolism in Azorean and Mainland Portuguese Populations: A Comparative Analysis

Current Issues in Molecular Biology
The frequency of specific variants associated with the risk of developing cardiovascular diseases has been extensively studied through genome-wide association studies (GWASs).
Luisa Mota-Vieira, Joana Duarte, Xavier Catena, Jaime Gonzalez, Andrea Capocci, Cláudia C. Branco   +5 more
doaj   +1 more source

Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history

, 2006
The major histocompatibility complex (MHC) is recognised as one of the most important genetic regions in relation to common human disease. Advancement in identification of MHC genes that confer susceptibility to disease requires greater knowledge of ...
John Trowsdale, Wilming, LG, Roberts Anne N, Coggill, P, Laurens G Wilming, Sarah Sims, Trowsdale, J, Atrazhev Alexey M, Palmer, S, Beck Stephan, Todd John A, Jane Rogers, Sawcer, S, Coggill Penny, Ashurst Jennifer L, Trowsdale John, Almeida Jeff, Alexey M Atrazhev, Elliott John F, Beck, S, Sophie Palmer, Hurles Matthew E, Traherne James A, Roberts, AN, Miretti, M, Stewart, CA, de Jong, PJ, Pieter J de Jong, Stephen Sawcer, Hurles, ME, James A Traherne, C Andrew Stewart, de Jong Pieter J., Matthew E Hurles, Horton, R, Penny Coggill, Jennifer L Ashurst, Sims, S, Horton Roger, Stewart C. Andrew, Almeida, J, Ashurst, JL, Carrington Mary, Elliott, JF, C. Andrew Stewart, Stephan Beck, Rogers Jane, Palmer Sophie, Pieter J. de Jong, Carrington, M, Rogers, J, Atrazhev, AM, Roger Horton, Sawcer Stephen, Traherne, JA, Jeff Almeida, Sims Sarah, John A Todd, Marcos M Miretti, Anne N Roberts, Wilming Laurens G, Todd, JA, Mary Carrington, Miretti Marcos M, John F Elliott   +64 more
core   +1 more source

CLINICAL AND GENETIC PARALLELS ALONG CELIAC DISEASE AMONG TOMSK CHILDREN

Педиатрическая фармакология, 2007
The article is devoted to the analysis of the genetic predisposition to celiac disease. The authors studied the associations of the HLA genes and modifier genes of the immune response (interleukine 1, inter leukine 1 receptor antagonist, inter leukine 4,
E.I. Kondrat’eva, V.P. Puzyrev, L.P. Nazarenko, A.A. Rudko, G.N. Yankina, E.V. Loshkova   +5 more
doaj   +2 more sources

Ethical, social and economic issues in familial breast cancer: a compilation of views from the EC biomed II demonstration project [PDF]

, 1999
: Demand for clinical services for familial breast cancer is continuing to rise across Europe. Service provision is far from uniform and, in most centres, its evolution has been determined by local conditions, specifically by local research ...
Hodgson, S, Haites, N., Stoppa-Lyonnet, D., Eccles, D, Stoppa-Lyonnet, D, Morrison, P., Eccles, D., Møller, P, Steel, M., Chang-Claude, J., Smyth, E., Moller, P., Evans, G.; id_orcid, Haites, N, Caligo, M., Steel, M, Hodgson, S., Vasen, H, Evans, G, Evans, G., Chang-Claude, J, Morrison, P, Smyth, E, Caligo, M, Vasen, H.   +24 more
core   +1 more source

Public Awareness of Genetic Influence on Chronic Disease Risk: Are Genetic and Lifestyle Causal Beliefs Compatible?

, 2011
Background/Aims: There is concern that raising awareness about the role of genetics in chronic disease etiology could undermine public belief that lifestyles are important, leading to adverse effects on public health. We tested the hypothesis that people
Sanderson, SC, Waller, J, Humphries, SE, Wardle, J   +3 more
core  

Pilot GWAS of caries in African-Americans shows genetic heterogeneity

BMC Oral Health, 2019
Background Dental caries is the most common chronic disease in the US and disproportionately affects racial/ethnic minorities. Caries is heritable, and though genetic heterogeneity exists between ancestries for a substantial portion of loci associated ...
E. Orlova, J. C. Carlson, M. K. Lee, E. Feingold, D. W. McNeil, R. J. Crout, R. J. Weyant, M. L. Marazita, J. R. Shaffer   +8 more
doaj   +1 more source