Results 51 to 60 of about 88,056,303 (299)

Association of Genetic Variations in Energy Metabolism Genes with Noise-Induced Hearing Loss in a Chinese Population: A Case–Control Study

Noise and Health
Objective: This study explored the relationship between susceptibility to single-nucleotide polymorphisms (SNP) and noise-induced hearing loss (NIHL) in a population exposed to occupational noise.
Bing Wang, Shanfa Yu, Jie Jiao, Guizhen Gu, Guoshun Chen, Wenhui Zhou, Hui Wu, Yanhong Li, Huanling Zhang   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Genetic Markers and Predisposition to Endometrial Neoplasms: A Systematic Review

OBJECTIVE: To identify genetic markers and understand their influence on the predisposition to endometrial neoplasms. METHODS: A systematic review was conducted between June and July 2024, following the Preferred Reporting Items for Systematic Reviews ...
Ana Clara Souza Dias Buffoni, Mario Cesar Tessarolo Saquetto, Fabiane Monteiro de Carvalho Souza Gomes, Lucas Sousa Pontes, Ana Paula Merscher Zanoni   +4 more
core   +6 more sources

Relationship between polymorphisms of DNA repair gene ERCC1 and susceptibility to lung cancer

Chinese Journal of Lung Cancer, 2008
Background and objective The recent studies have demonstrated that polymorphisms of DNA repair genes can impact the tumor susceptibility. So the susceptible group can be chosen through analysis of different genotype of DNA repair genes and maybe get the ...
Bo SU, Jie ZHANG, Liang TANG, Zengli ZHANG, Caicun ZHOU   +4 more
doaj  

Identification of DICER1 Syndrome on the Basis of Familial, Early‐Onset Differentiated Thyroid Cancer

Clinical Case Reports
DICER1 syndrome encompasses a wide range of phenotypes, and not all individuals with DICER1 syndrome develop aggressive soft tissue tumors. DICER1 syndrome and other genetic conditions predisposing to the development of thyroid tumors should be ...
Jessica Y. Wong, Alex Henderson, Simon Harper, Richard W. Carroll, Peter B. Bethwaite, Esko Wiltshire   +5 more
doaj   +1 more source

Agregación familiar en el síndrome de colon irritable en pacientes mexicanos. Un estudio de casos y controles

Atención Primaria
Resumen: Objetivo: Determinar la existencia de un patrón familiar de agregación del síndrome de intestino irritable (SII). Diseño: Es un estudio de casos y controles con proporción 1:2, llevado a cabo en una consulta externa de medicina general-familiar.
José M. Ramírez Aranda, Cinthya M. Martínez Gutiérrez, Mariano M. Fuentes Ramírez, Martín R. Escobedo Ríos, Fernanda del R. Delgado Cuevas   +4 more
doaj   +1 more source

Genetic polymorphisms in lung disease: bandwagon or breakthrough?

Respiratory Research, 2002
The study of genetic polymorphisms has touched every aspect of pulmonary and critical care medicine. We review recent progress made using genetic polymorphisms to define pathophysiology, to identify persons at risk for pulmonary disease and to predict ...
Rybicki Benjamin, Maliarik Mary, Iannuzzi Michael C   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Genetic Predisposition to SARS-CoV-2 Infection: Cytokine Polymorphism and Disease Transmission within Households

Biology, 2023
We addressed the question of the influence of the molecular polymorphism of cytokines from different T helper subsets on the susceptibility to SARS-CoV-2 infection. From a cohort of 527 samples (collected from 26 May 2020 to 31 March 2022), we focused on
Marius Saal, Henry Loeffler-Wirth, Thomas Gruenewald, Ilias Doxiadis, Claudia Lehmann   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source