Results 41 to 50 of about 88,056,303 (299)

Prediction of sepsis-related outcomes in neonates through systematic genotyping of polymorphisms in genes for innate immunity and inflammation: a narrative review and critical perspective

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Neonatal sepsis is associated with premature birth and maternal infection. Large-scale studies seek to define markers that identify neonates at risk of developing sepsis.
Juliana Kilesse Carvalho, Daniella Batalha Moore, Ricardo Alves Luz, Pedro Paulo Xavier-Elsas, Maria Ignez Capella Gaspar-Elsas   +4 more
doaj   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history [PDF]

, 2006
The major histocompatibility complex (MHC) is recognised as one of the most important genetic regions in relation to common human disease. Advancement in identification of MHC genes that confer susceptibility to disease requires greater knowledge of ...
John Trowsdale, Wilming, LG, Roberts Anne N, Coggill, P, Laurens G Wilming, Sarah Sims, Trowsdale, J, Atrazhev Alexey M, Palmer, S, Beck Stephan, Todd John A, Jane Rogers, Sawcer, S, Coggill Penny, Ashurst Jennifer L, Trowsdale John, Almeida Jeff, Alexey M Atrazhev, Elliott John F, Beck, S, Sophie Palmer, Hurles Matthew E, Traherne James A, Roberts, AN, Miretti, M, Stewart, CA, de Jong, PJ, Pieter J de Jong, Stephen Sawcer, Hurles, ME, James A Traherne, C Andrew Stewart, de Jong Pieter J., Matthew E Hurles, Horton, R, Penny Coggill, Jennifer L Ashurst, Sims, S, Horton Roger, Stewart C. Andrew, Almeida, J, Ashurst, JL, Carrington Mary, Elliott, JF, C. Andrew Stewart, Stephan Beck, Rogers Jane, Palmer Sophie, Pieter J. de Jong, Carrington, M, Rogers, J, Atrazhev, AM, Roger Horton, Sawcer Stephen, Traherne, JA, Jeff Almeida, Sims Sarah, John A Todd, Marcos M Miretti, Anne N Roberts, Wilming Laurens G, Todd, JA, Mary Carrington, Miretti Marcos M, John F Elliott   +64 more
core   +1 more source

Genetic predisposition to metabolic dysfunction-associated fatty liver disease

Zdorovʹe Rebenka
The literature review highlights the issue of genetic risk factors associated with the development of metabolic dysfunction-associated fatty liver disease. Human genetic examinations revealed 132 genes among which 32 loci are strongly associated with the
O.E. Abaturov, A.O. Nikulina
doaj   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Genetic Predisposition to Recurrent Aphthous Stomatitis

, 2017
Background: Recurrent aphthous stomatitis (RAS), one of the most common diseases of the oral mucosa, is characterized by the formation of painful oral erosions or even ulcers.
L. Hollá, L. Izakovičová Hollá, P. Bořilová Linhartová, S. Valová, P. Linhartová   +4 more
core   +1 more source

Discovery of Sexual Dimorphisms in Metabolic and Genetic Biomarkers [PDF]

, 2011
Metabolomic profiling and the integration of whole-genome genetic association data has proven to be a powerful tool to comprehensively explore gene regulatory networks and to investigate the effects of genetic variation at the molecular level.
Polonikov, Alexey, Wichmann, Heinz-Erich, Fabian J. Theis, Stephan Weidinger, Wichmann Heinz Erich, Gieger, C., Ried, Janina S., Christian Gieger, Krumsiek, J., Karsten Suhre, Prehn, C., Kirstin Mittelstrass, Heinz Erich Wichmann, Polonikov, A., Weidinger, S., Alexey Polonikov, Werner Roemisch-Margl, Yu Zhonghao, Theis, F.J., Wang-Sattler, R., Jan Krumsiek, Ried Janina S., Yu, Z., Gieger Christian, Mittelstrass, Kirstin, Wichmann, H.-E., Polonikov Alexey, Illig, T., Fabian J Theis, Peters, Annette, Illig Thomas, Mittelstrass Kirstin, Zhonghao Yu, Theis, Fabian J., Peters Annette, Kronenberg Florian, Florian Kronenberg, Jerzy Adamski, Annette Peters, Wang-Sattler, Rui, Krumsiek, Jan, Theis Fabian J., Peters, A., Krumsiek Jan, Illig, Thomas, Roemisch-Margl Werner, Wang-Sattler Rui, Meitinger, Thomas, Adamski, Jerzy, Ried, J.S., Cornelia Prehn, Thomas Illig, Römisch-Margl, W., Suhre Karsten, Gieger, Christian, Weidinger, Stephan, Weidinger Stephan, Suhre, K., Roemisch-Margl, Werner, Kronenberg, Florian, Yu, Zhonghao, Adamski Jerzy, Thomas Meitinger, Meitinger, T., Prehn, Cornelia, Rui Wang-Sattler, Kronenberg, F., Janina S. Ried, Prehn Cornelia, Adamski, J., Mittelstraß, K., Suhre, Karsten, Janina S Ried, Meitinger Thomas, Mittelstrass, K;Ried, JS;Yu, Z;Krumsiek, J;Gieger, C;Prehn, C;Roemisch-Margl, W;Polonikov, A;Peters, A;Theis, FJ;Meitinger, T;Kronenberg, F;Weidinger, S;Wichmann, HE;Suhre, K;Wang-Sattler, R;Adamski, J;Illig, T, Mittelstraß, K. ; Ried, J.S. ; Yu, Z. ; Krumsiek, J. ; Gieger, C. ; Prehn, C. ; Römisch-Margl, W. ; Polonikov, A. ; Peters, A. ; Theis, F.J. ; Meitinger, T. ; Kronenberg, F. ; Weidinger, S. ; Wichmann, H.-E. ; Suhre, K. ; Wang-Sattler, R. ; Adamski, J. ; Illig, T.   +75 more
core   +1 more source

Polygenic risk score refines cardiovascular disease risk in individuals with type 2 diabetes at borderline or intermediate risk

Journal of Diabetes Investigation
To evaluate whether a coronary artery disease (CAD) polygenic risk score (PRS) can improve atherosclerotic cardiovascular disease (ASCVD) risk stratification in individuals with type 2 diabetes (T2D), particularly those at borderline or intermediate 10 ...
Jaewon Choi, Hyunsuk Lee, Tae‐Min Rhee, Jun‐Bean Park, Soo Heon Kwak   +4 more
doaj   +1 more source

Genetic cause of pulmonary veno-occlusive disease

Lung India, 2022
Pulmonary veno-occlusive disease (PVOD) is an important cause of pulmonary arterial hypertension (PAH) and is classified under idiopathic cause of PAH. Over a period of time, PVOD has been studied in detail in the western countries and various diagnostic
Kaustubh Mohite, Anil Kumar Sapare
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source