Results 21 to 30 of about 319,093 (308)

Genetic predisposition and the variable course of infectious diseases

Deutsches Ärzteblatt international, 2022
Contact with a pathogen is followed by variable courses of infectious disease, which are only partly explicable by classical risk factors. The susceptibility to infection is variable, as is the course of disease after infection. In this review, we discuss the extent to which this variation is due to genetic factors of the affected individual (the host).
Axel, Schmidt, Ana M, Groh, Julia S, Frick, Maria J G T, Vehreschild, Kerstin U, Ludwig   +4 more
openaire   +2 more sources

Risk of newly developed atrial fibrillation by alcohol consumption differs according to genetic predisposition to alcohol metabolism: a large-scale cohort study with UK Biobank

BMC Medicine, 2023
Background The predictive relationship between mild-to-moderate alcohol consumption and the risk of incident atrial fibrillation (AF) remains controversial.
Chan Soon Park, Jaewon Choi, JungMin Choi, Kyung-Yeon Lee, Hyo-Jeong Ahn, Soonil Kwon, So-Ryoung Lee, Eue-Keun Choi, Soo Heon Kwak, Seil Oh   +9 more
doaj   +1 more source

Sleep characteristics modify the association between genetic predisposition to obesity and anthropometric measurements in 119,679 UK Biobank participants [PDF]

, 2017
Background - Obesity is a multifactorial condition influenced by genetics, lifestyle and environment. Objective - To investigate whether the association between a validated genetic profile risk score for obesity (GPRS-obesity) with body mass index (BMI)
Bailey, Mark E.S., Biello, Stephany M., Celis-Morales, Carlos, Gill, Jason M.R., Guo, Yibing, Llamas, Daniel, Lyall, Donald M., Mackay, Daniel F., Pell, Jill P., Steell, Lewis, Ward, Joey   +10 more
core   +1 more source

Genetic Predisposition to Respiratory Diseases: Infiltrative Lung Diseases [PDF]

Respiration, 2006
The availability of high-throughput genotyping and large collaborative clinical networks creating well-characterized patient populations with DNA repositories has facilitated genome-wide scans and candidate gene studies to identify susceptibility alleles for the development of interstitial lung disease.
Mark P, Steele, Kevin K, Brown
openaire   +2 more sources

A multi-factorial genetic model for prognostic assessment of high risk melanoma patients receiving adjuvant interferon [PDF]

, 2012
Purpose: IFNa was the first cytokine to demonstrate anti-tumor activity in advanced melanoma. Despite the ability of high-dose IFNa reducing relapse and mortality by up to 33%, large majority of patients experience side effects and toxicity which ...
Alessandro Monaco, Ena Wang, Francesco M. Marincola, Helen Gogas, John M. Kirkwood, Lorenzo Uccellini, Maria Spyropoulou-Vlachou, Monica C. Panelli, Sophia N. Karagiannis, Yingdong Zhao   +9 more
core   +10 more sources

Detection of Rs9939609 Polymorphism of Fto Gene and Rs324011 Polymorphism of Stat6 Gene and Severity Degree of Bronchial Asthma Associated with Obesity [PDF]

, 2017
The aim of this research was to analyze the distribution of FTO and STAT6 genes polymorphism in patients with bronchial asthma (BA), associated with obesity (Ob) depending on the main disease severity degree.Materials and methods.
Fediv, A. (Alexander), Melnik, E. (Elena)   +1 more
core   +2 more sources

MiRNA-34 and stress response [PDF]

, 2017
Psychiatric disorders are known to result from a strong interaction between genetic predisposition and environmental factors, mainly exposure to stressful events. Environmental events can modulate genes expression, possibly via epigenetic mechanisms, and
Andolina, Diego, DI SEGNI, Matteo, Ventura, Rossella   +2 more
core   +1 more source

Genetic predisposition in nonalcoholic fatty liver disease [PDF]

Clinical and Molecular Hepatology, 2017
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease whose prevalence has reached global epidemic proportions. Although the disease is relatively benign in the early stages, when severe clinical forms, including nonalcoholic steatohepatitis (NASH), cirrhosis and even hepatocellular carcinoma, occur, they result in worsening
Sookoian, Silvia Cristina, Pirola, Carlos José   +1 more
openaire   +4 more sources

International Veterinary Epilepsy Task Force consensus proposal: Medical treatment of canine epilepsy in Europe [PDF]

, 2015
In Europe, the number of antiepileptic drugs (AEDs) licensed for dogs has grown considerably over the last years. Nevertheless, the same questions remain, which include, 1) when to start treatment, 2) which drug is best used initially, 3) which ...
A Fischer, A Khoutorsky, A Tipold, AJ Streeter, AJ Wilensky, AK Cook, Akos Pakozdy, AM Kiviranta, Andrea Fischer, Andrea Tipold, B Dayrell-Hart, BF Bourgeois, C O'Dell, C Rundfeldt, C Rundfeldt, CH Gulløv, CL Gaskill, CL Gaskill, Clare Rusbridge, CW Dewey, CW Dewey, CW Dewey, D Ruehlmann, D Schwartz-Porsche, DJ Morton, DM Boothe, DM Boothe, DW Chadwick, DW Kaufman, Edward E. Patterson, EE Patterson, ES Nichols, F Al-Tahan, G Hussein, G Jacobs, GC Farnbach, GD Montouris, GD Thurman, GJ Sills, GW Caldwell, H Freitag, HA Volk, HE Baird-Heinz, Heidrun Potschka, HH Frey, HH Frey, HM Wright, Holger A. Volk, HS White, IC Wong, IE Leppik, IH Shaik, J Janszky, J Speciale, J Weissl, Jacques Penderis, JJ Shih, JJ Shih, JM Pellock, JT Yarrington, JY Chung, K Orito, KA Lyseng-Williamson, Karen Muñana, Kaspar Matiasek, KL Weiss, KR Muñana, KR Muñana, KR Muñana, L Alves, L Risio De, LA Trepanier, LA Trepanier, LA Trepanier, LA Trepanier, LD Cahan, LJ Stephen, LL Radulovic, Luisa De Risio, M Berendt, M Berendt, M Bialer, M Charalambous, M Govendir, M Podell, M Podell, M Podell, M Podell, M Schwartz, M Taverna, M1 Contin, MA Rogawski, Mette Berendt, MFD Steinberg, Michael Podell, ML Miller, N Scola, P Jull, P Kwan, PA March, PA March, Paul J.J. Mandigers, PB Müller, PN Patsalos, R Monteiro, RD Elterman, RE Levitski, RM Packer, Robyn G. Farquhar, RS Hess, S Daminet, S Rieck, S Shorvon, SA Kube, SA Moore, SA Moore, Sam Long, SD Forrester, SD Shorvon, SE Bunch, SE Martinez, SI Johannessen, Simon Platt, SM Roche La, SO Wagner, Sofie F.M. Bhatti, SR Platt, T Glauser, T Hojo, T Klopmann von, T Klopmann von, TA Glauser, TL Gieger, TL Gieger, TP Sutula, V Hülsmeyer, V Salazar, VE Adusumalli, Veronika M. Stein, W Löscher, W Löscher, WB Thomas, WB Thomas, WM Pedersoli, Wolfgang Löscher, WR Garnett, WR Ravis, WR Ravis, Y Heynold   +148 more
core   +7 more sources

Cholesteatoma and family history: An international survey [PDF]

, 2020
Objective To explore the relative frequency of a family history of cholesteatoma in patients with known cholesteatoma, and whether bilateral disease or earlier diagnosis is more likely in those with a family history.
Clark, Allan, Collins, Rachael, Hong Ta, Ngan, Jennings, Barbara A., Philpott, Carl M., Prinsley, Peter, Steel, Nick   +6 more
core   +1 more source