Results 21 to 30 of about 208,174 (208)

Genetic Predisposition and Inflammatory Bowel Disease [PDF]

Gastroenterology Research, 2013
Published reports demonstrated finding of different susceptible mutant alleles in association with inflammatory bowel disease (CD/UC) in diseased individuals from different populations. It was then assumed that the existence of different associated mutant alleles in subjects with inflammatory bowel disease from different populations means different ...
openaire   +2 more sources

The expressivist objection to prenatal testing : the experiences of families living with genetic disease [PDF]

, 2014
The expressivist objection to prenatal testing is acknowledged as a significant critique of prenatal testing practices most commonly advanced by disability rights supporters.
Felicity Kate Boardman, Boardman, Felicity Kate, Boardman, Felicity K.   +2 more
core   +1 more source

Genetic predisposition and the variable course of infectious diseases

Deutsches Ärzteblatt international, 2022
Contact with a pathogen is followed by variable courses of infectious disease, which are only partly explicable by classical risk factors. The susceptibility to infection is variable, as is the course of disease after infection. In this review, we discuss the extent to which this variation is due to genetic factors of the affected individual (the host).
Axel, Schmidt, Ana M, Groh, Julia S, Frick, Maria J G T, Vehreschild, Kerstin U, Ludwig   +4 more
openaire   +2 more sources

Genetic Predisposition to Respiratory Diseases: Infiltrative Lung Diseases [PDF]

Respiration, 2006
The availability of high-throughput genotyping and large collaborative clinical networks creating well-characterized patient populations with DNA repositories has facilitated genome-wide scans and candidate gene studies to identify susceptibility alleles for the development of interstitial lung disease.
Mark P, Steele, Kevin K, Brown
openaire   +2 more sources

Environmental interventions and the pattern of geohelminth infections in Salvador, Brazil. [PDF]

, 2004
This paper reports a longitudinal study, conducted in 1989/90, of 1893 children aged 5 to 14 years in 9 poor urban areas of the city of Salvador (population 2.44 million), capital of Bahia State in northeast Brazil.
Moraes, LRS, Cairncross, S
core   +1 more source

Genetic predisposition in nonalcoholic fatty liver disease [PDF]

Clinical and Molecular Hepatology, 2017
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease whose prevalence has reached global epidemic proportions. Although the disease is relatively benign in the early stages, when severe clinical forms, including nonalcoholic steatohepatitis (NASH), cirrhosis and even hepatocellular carcinoma, occur, they result in worsening
Sookoian, Silvia Cristina, Pirola, Carlos José   +1 more
openaire   +4 more sources

Germline MBD4 deficiency causes a multi-tumor predisposition syndrome [PDF]

, 2022
We report an autosomal recessive, multi-organ tumor predisposition syndrome, caused by bi-allelic loss-of-function germline variants in the base excision repair (BER) gene MBD4.
Nuria Lopez-Bigas, Trevor Graham, Yael Goldberg, Andrea Sottoriva, Lynn Martin, Judith E. Grolleman, Sara Galavotti, Nicola Lander, Simone A.M. van der Biezen, Laura E. Thomas, Laura Chegwidden, Edward H. Arbe-Barnes, David J. Adams, William Cross, Kitty Sherwood, Demetra Georgiou, Florentia Fostira, Constantinos Deltas, Dagmara Dymerska, Christoffer Flensburg, Richard Houlston, Tom van Wezel, Huw Thomas, Khalid Mahmood, Lilian Vreede, Mark Clendenning, Aleksandar J. Dimovski, Edward Chew, Rachel S. van der Post, Boris Noyvert, Ashish Bajel, Daniel Chubb, Judith Pagan, Celina Whalley, Rebekah Truscott, Claire Palles, David Church, Hannah D. West, Michael Christie, Giulio Caravagna, Andreas J. Gruber, Clare Turnbull, Ben Kinnersley, Claudia Arnedo-Pac, Jenny C. Taylor, Erik A.M. Jansen, Helen Curley, Mathijs Sanders, Jan Lubinski, Anna Frangou, Jürgen Weitz   +50 more
core   +1 more source

Spatial and genetic epidemiology of hookworm in a rural community in Uganda. [PDF]

, 2010
There are remarkably few contemporary, population-based studies of intestinal nematode infection for sub-Saharan Africa. This paper presents a comprehensive epidemiological analysis of hookworm infection intensity in a rural Ugandan community ...
Pullan, Rachel L, Pullan, RL, Quinnell, Rupert J, Brooker Simon, Brooker, Simon, Quinnell, RJ, Narcis B Kabatereine, Rupert J Quinnell, Brooker, S, Quinnell Rupert J., Rupert J. Quinnell, Simon Brooker, Pullan Rachel L., Kabatereine Narcis B., Kabatereine, NB, Kabatereine, Narcis B, Rachel L. Pullan, Narcis B. Kabatereine, Rachel L Pullan   +18 more
core   +1 more source

Periodontal disease: a genetic perspective

Brazilian Oral Research, 2012
Periodontitis is a multifactorial disease that causes tooth loss. The complex pathogenesis of periodontitis implies the involvement of a susceptible host and a bacterial challenge.
Mario Taba Jr, Sergio Luis Scombatti de Souza, Viviane Casagrande Mariguela   +2 more
doaj   +1 more source

Glutathione S-transferase T1 and M1 polymorphisms and risk of thyroid neoplasms [PDF]

Archive of Oncology, 2003
Background: In order to test the possibility of association between GSTT1 and M1 (glutathione S-transferase) null allele variant, in which the entire gene is absent, and the risk of TCO (thyroid carcinoma with cell oxyphilia), the case-control study was ...
Stankov Karmen, Landi Stefano, Volante Marco, Papotti Mauro   +3 more
doaj   +1 more source