Results 11 to 20 of about 208,174 (208)

Genetic predisposition to smoking in relation to 14 cardiovascular diseases

European Heart Journal, 2020
Abstract Aims The aim of this study was to use Mendelian randomization (MR) to determine the causality of the association between smoking and 14 different cardiovascular diseases (CVDs). Methods and results Our primary genetic ...
Larsson, Susanna C, Mason, Amy M, Bäck, Magnus, Klarin, Derek, Damrauer, Scott M, Million Veteran Program, Michaëlsson, Karl, Burgess, Stephen   +7 more
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Physical activity, genetic predisposition, and incident cardiovascular disease: Prospective analyses of the UK Biobank [PDF]

Journal of Sport and Health Science
Background: It is unclear whether physical activity can benefit participants with high genetic predisposition to cardiovascular disease. We examined the joint associations of intensity-specific physical activity and genetic predisposition (based on ...
Matthew N. Ahmadi, Hamish D. Mundell, Greg T. Sutherland, Mark Hamer, Elina Sillanpää, Joanna M. Blodgett, Borja del Pozo Cruz, Emmanuel Stamatakis   +7 more
doaj   +4 more sources

The effect of type 2 diabetes genetic predisposition on non-cardiovascular comorbidities

Nature Communications
Type 2 diabetes is associated with a range of non-cardiovascular non-oncologic comorbidities. To move beyond associations and evaluate causal effects between type 2 diabetes genetic predisposition and 21 comorbidities, we apply Mendelian randomization ...
Ana Luiza Arruda, Ozvan Bocher, Henry J. Taylor, Davis Cammann, Satoshi Yoshiji, Xianyong Yin, Chi Zhao, Jingchun Chen, Alexis C. Wood, Ken Suzuki, Josep M. Mercader, Cassandra N. Spracklen, James B. Meigs, Marijana Vujkovic, George Davey Smith, Jerome I. Rotter, Benjamin F. Voight, Andrew P. Morris, Eleftheria Zeggini   +18 more
doaj   +3 more sources

Genetic Predisposition to Thrombophilia in Inflammatory Bowel Disease [PDF]

Journal of Clinical Gastroenterology, 2011
Inflammatory bowel disease (IBD) is linked to a definite risk of thromboembolic events (TE), but data on the role of prothrombotic genetic mutations are conflicting.Fourteen genetic factors involved in TE pathogenesis were investigated in a homogeneous cohort of Sicilian patients with IBD with and without history of TE and in healthy controls.
Cappello, M, GRIMAUDO, Stefania, BRAVATA', Ivana, RANDAZZO, Claudia, PIPITONE, Rosaria Maria, LICATA, Anna, CAMMA', Calogero, CRAXI, Antonio   +7 more
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Genetic Predisposition to Infectious Disease [PDF]

Cureus, 2018
In contemporary medical practice, approaches to infectious disease management have been primarily rooted in a pathogen-centered model. However, host genetics also contribute significantly to infectious disease burden. The fast expansion of bioinformatics techniques and the popularization of the genome-wide association study (GWAS) in recent decades ...
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Genetic predisposition, Aβ misfolding in blood plasma, and Alzheimer’s disease

, 2021
Alzheimer's disease is highly heritable and characterized by amyloid plaques and tau tangles in the brain. The aim of this study was to investigate the association between genetic predisposition, Aβ misfolding in blood plasma, a unique marker of ...
Nabers, Andreas, , Laura, Hartmann, Annette M., Holleczek, Bernd, Möllers, Tobias, Stocker, Hannah, Stockmann, Julia, Gerwert, Klaus, Brenner, Hermann, Rujescu, Dan, Schöttker, Ben   +10 more
core   +2 more sources

Genome-Wide Scan Identifies TNIP1, PSORS1C1, and RHOB As Novel Risk Loci for Systemic Sclerosis [PDF]

, 2011
Systemic sclerosis (SSc) is an orphan, complex, inflammatory disease affecting the immune system and connective tissue. SSc stands out as a severely incapacitating and life-threatening inflammatory rheumatic disease, with a largely unknown pathogenesis ...
P. Amouyel, MELCHERS I, Cusi, D., Amouye, Philippe, Jerome Avouac, Melchers, Inga, Salvi Erika, Müller, Martina, ALLANORE Y, Damjanov Nemanja, Meyer Oliver, HACHULLA E, Nemanja Damjanov, Hunzelmann Nicolas, I. Melchers, H.-Erich Wichmann, Wichmann, H.-E., Ulf Müller-Ladner, Lambert, J.C., Ruiz, B., AMOUYEL P, Munnich, A., Riemekasten, Gabriella, Cracowski Jean-Luc, Distler, J.H., AVOUAC J, CONTI C, Hachulla Eric, Dupuy, Anne-Marie, Dieude, Philippe, AIRO P, Munnich Arnold, Caramaschi, Paola, Avouac, Jerome, Nicolas Hunzelmann, Inga Melchers, Lambert J. C, Allanore, Y., C. Boileau, Conti, Costanza, Diot, Elisabeth, Lambert Jean-Charles, A. M. Dupuy, O. Meyer, Yannick Allanore, Avouac, J., Martinez, Maria, Ruiz Barbara, Otylia Kowal Bielecka, Wichmann, H-Erich, Luc Letenneur, J. Avouac, P. Caramaschi, Mouthon Luc, Wipff, J., Wichmann, H.-Erich, Dieudé Philippe, C. Conti, Meyer, O., E. Hachulla, M. Müller, Mouthon, L., Arnold Munnich, Avouac Jérôme, Damjanov, Nemanja, Gabriele Valentini, Valentini, G., Müller-Ladner Ulf, Caramaschi Paola, Müller, M., Tiev, Kiet, Martinez, M., Meyer, Oliver, MARTINEZ M., Kowal-Bielecka, O., H. Erich Wichmann, Distler, Jorg, H. W., A. Munnich, Matucci-Cerinic Marco, Dupuy Anne Marie, László Czirjak, G. Valentini, DAMJANOV N, MEYER O, Kahan, Andre, Melchers Inga, RICCIERI V, Saad, M., Jorg H W Distler, Cusi Daniele, Ruiz, Barbara, Kahan André, Martina Muller, E. Salvi, WIPFF J, E. Diot, Distler J, Müller Martina, CARAMASCHI P, DIOT E, Erika Salvi, J. C. Lambert, HUNZELMANN N, Matucci-Cerinic, M., Boileau, Catherine, Dieudé, P., Airo, P., Cusi, Daniele, Riccieri, Valeria, Müller-Ladner, U., J. Wipff, L. Czirják, Distler, Jorg H. W., Hachulla, E., Czirjak, Laszlo, Czijak L, Y. Allanore, MUNNICH A, Mohamad Saad, Czirják, L., Wipff, Julien, K. Tiev, L. Letenneur, Letenneur, Luc, Maria Martinez, Conti Costanza, Airo Paolo, Kowal-Bielecka, Otylia, N. Damjanov, MÜLLER LADNER U, SALVI E, WICHMANN HE, Valentini Gabriele, Jorg H. W. Distler, Paolo Airo, DUPUY AM, Valentini G, CUSI D, MÜLLER M, Mouthon, Luc, J. L. Cracowski, Damjanov, N., LAMBERT JC, Distler Jorg H. W., H-Erich Wichmann, P. Dieudé, Diot, E., MATUCCI CERINIC, Marco, Paola Caramaschi, Valentini, Gabriele, Hachulla, Eric, Jean Luc Cracowski, Tiev Kiet, CRACOWSKI JL, Airo, Paolo, Costanza Conti, Jean-Charles Lambert, RUIZ B, Daniele Cusi, Martinez Maria, Valeria Riccieri, M. Matucci Cerinic, MATUCCI CERINIC M, Eric Hachulla, H. E. Wichmann, Lambert, Jean-Charles, Wichmann, Heinz-Erich, Tiev, K., Kiet Tiev, Catherine Boileau, MOUTHON L, Riemekasten, G., Jean Charles Lambert, L. Mouthon, Caramaschi, P., Marco Matucci-Cerinic, SAAD M, B. Ruiz, Riemekasten Gabriella, J. H. Distler, BOILEAU C, Boileau Catherine, Philippe Amouyel, Riccieri Valeria, Munnich, Arnold, Cracowski, Jean-Luc, Gabriella Riemekasten, DIEUDÉ P, N. Hunzelmann, Saad Mohamad, Letenneur Luc, Czirják László, Allanore, Yannick, Philippe Dieude, Julien Wipff, Müller-Ladner, Ulf, KOWAL BIELECKA O, LETENNEUR L, Kowal-Bielecka Otylia, Elisabeth Diot, G. Riemekasten, KAHAN A, Wichmann H.-Erich, Salvi, E., Matucci-Cerinic, Marco, Dupuy, A.M., D.M. Cusi, Oliver Meyer, U. Müller Ladner, Hunzelmann, Nicolas, Allanore Yannick, Wipff Julien, Cracowski, J.L., Saad, Mohamad, Barbara Ruiz, RIEMEKASTEN G, O. Kowal Bielecka, Conti, C., M. Martinez, Jean-Luc Cracowski, P. Airo, CZIRJÁK L, Amouyel, Philippe, Letenneur, L., Salvi, Erika, DISTLER JH, Amouyel, P., Distler, Jorg,, Luc Mouthon, V. Riccieri, Hunzelmann, N., Ulf Muller Ladner, TIEV K, Dupuy, Anne Marie, Diot Elisabeth, Kahan, A., Riccieri, V., Marco Matucci Cerinic, André Kahan, Boileau, C., M. Saad, A. Kahan, Anne Marie Dupuy, Amouyel Philippe, Otylia Kowal-Bielecka, Melchers, I.   +245 more
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Genetic and Epigenetic Etiology of Inflammatory Bowel Disease: An Update

, 2022
Inflammatory bowel disease (IBD) is a chronic disease with periods of exacerbation and remission of the disease. The etiology of IBD is not fully understood. Many studies point to the presence of genetic, immunological, environmental, and microbiological
Rafał Filip, Sokal, Aneta, Magdalena Zielińska, Sara Jarmakiewicz-Czaja, Aneta Sokal, Jarmakiewicz-Czaja, Sara, Filip, Rafał, Zielińska, Magdalena   +7 more
core   +1 more source

Genetic predisposition of cholesterol gallstone disease

Annals of Hepatology, 2006
Gallstone disease (GSD) is the result of the interaction between genetic and environmental factors and it is a major disease cause of surgery with high costs to health systems. Worldwide prevalence varies according to the ethnic population suggesting that high prevalence of GSD in certain ethnic groups is due to the presence of genetic factors ...
Alejandro Hernández-Nazará, Fátima Curiel-López, Erika Martínez-López, Zamira Hernández-Nazará, Arturo Panduro   +4 more
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Venous Thromboembolism in Kidney Diseases and Genetic Predisposition

Kidney Diseases, 2022
<b><i>Background:</i></b> Many renal diseases have been associated with profound clinical effects on thrombosis. To our knowledge, patients with nephrotic syndrome (NS) and chronic kidney disease (CKD) display an elevated risk of vein thrombosis, which is among the common causes of mortality in patients with renal diseases.
Tingting Wu, Liang V. Tang, Yu Hu
openaire   +3 more sources