Genetic predisposition to thrombophilia in inflammatory bowel disease [PDF]
Journal of Clinical Gastroenterology, 2011 Inflammatory bowel disease (IBD) is linked to a definite risk of thromboembolic events (TE), but data on the role of prothrombotic genetic mutations are conflicting.Fourteen genetic factors involved in TE pathogenesis were investigated in a homogeneous cohort of Sicilian patients with IBD with and without history of TE and in healthy controls.
BRAVATA', Ivana +7 more
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Family-specific, novel, deleterious germline variants provide a rich resource to identify genetic predispositions for BRCAx familial breast cancer [PDF]
, 2014 BACKGROUND: Genetic predisposition is the primary risk factor for familial breast cancer. For the majority of familial breast cancer, however, the genetic predispositions remain unknown.
Bradley Downs +11 more
core +3 more sources
Genetic Predisposition to Infectious Disease [PDF]
Cureus, 2018 In contemporary medical practice, approaches to infectious disease management have been primarily rooted in a pathogen-centered model. However, host genetics also contribute significantly to infectious disease burden. The fast expansion of bioinformatics techniques and the popularization of the genome-wide association study (GWAS) in recent decades ...
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Genetic Predisposition to High Blood Pressure Associates With Cardiovascular Complications Among Patients With Type 2 Diabetes: Two Independent Studies [PDF]
, 2014 Hypertension and type 2 diabetes (T2D) commonly coexist, and both conditions are major risk factors for cardiovascular disease (CVD). We aimed to examine the association between genetic predisposition to high blood pressure and risk of CVD in individuals
Curhan, Gary C. +7 more
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Genome-wide analysis of the mouse lung transcriptome reveals novel molecular gene interaction networks and cell-specific expression signatures [PDF]
, 2011 The lung is critical in surveillance and initial defense against pathogens. In humans, as in mice, individual genetic differences strongly modulate pulmonary responses to infectious agents, severity of lung disease, and potential allergic reactions. In a
Rudi Alberts +3 more
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Erythrocytes in multiple sclerosis: forgotten contributors to the pathophysiology? [PDF]
, 2016 Multiple sclerosis (MS) is an autoimmune disease characterised by lymphocytic infiltration of the central nervous system and subsequent destruction of myelin and axons. On the background of a genetic predisposition to autoimmunity, environmental triggers
Groen, Kira +5 more
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Genetic predisposition of cholesterol gallstone disease
Annals of Hepatology, 2006 Gallstone disease (GSD) is the result of the interaction between genetic and environmental factors and it is a major disease cause of surgery with high costs to health systems. Worldwide prevalence varies according to the ethnic population suggesting that high prevalence of GSD in certain ethnic groups is due to the presence of genetic factors ...
Alejandro Hernández-Nazará +4 more
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Venous Thromboembolism in Kidney Diseases and Genetic Predisposition
Kidney Diseases, 2022 <b><i>Background:</i></b> Many renal diseases have been associated with profound clinical effects on thrombosis. To our knowledge, patients with nephrotic syndrome (NS) and chronic kidney disease (CKD) display an elevated risk of vein thrombosis, which is among the common causes of mortality in patients with renal diseases.
Tingting Wu, Liang V. Tang, Yu Hu
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Genetic Predisposition and Inflammatory Bowel Disease [PDF]
Gastroenterology Research, 2013 Published reports demonstrated finding of different susceptible mutant alleles in association with inflammatory bowel disease (CD/UC) in diseased individuals from different populations. It was then assumed that the existence of different associated mutant alleles in subjects with inflammatory bowel disease from different populations means different ...
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Prevalence and breed predisposition for thoracolumbar intervertebral disc disease in cats [PDF]
, 2016 Objectives The objective was to evaluate the prevalence and possible breed predilections for thoracolumbar intervertebral disc disease (IVDD) in cats. Methods Medical records and imaging studies of cats diagnosed with thoracolumbar IVDD between January ...
De Decker, S, Volk, H A, Warner, A-S
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