Results 101 to 110 of about 9,566,413 (315)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Genetic programming in data mining for drug discovery [PDF]
, 2004 Genetic programming (GP) is used to extract from rat oral bioavailability (OB) measurements simple, interpretable and predictive QSAR models which both generalise to rats and to marketed drugs in humans. Receiver Operating Characteristics (ROC) curves
Barrett, S.J., Langdon, W.B.
core +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Evolution of a robotic soccer player [PDF]
, 2002 Robotic soccer is a complex domain where, rather than hand-coding computer programs to control the players, it is possible to create them through evolutionary methods.
Walker, Matthew
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
A NEW MUTATION OPERATOR IN GENETIC PROGRAMMING [PDF]
ICTACT Journal on Soft Computing, 2013 This paper proposes a new type of mutation operator, FEDS (Fitness, Elitism, Depth, and Size) mutation in genetic programming. The concept behind the new mutation operator is inspired from already introduced FEDS crossover operator to handle the problem ...
Anuradha Purohit +2 more
doaj
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Rule Extraction by Genetic Programming with Clustered Terminal Symbols [PDF]
, 2009 When Genetic Programming (GP) is applied to rule extraction from databases, the attributes of the data are often used for the terminal symbols. However, in the case of the database with a large number of attributes, the search space becomes vast because ...
Hara, Akira +3 more
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Evolution of the discrete cosine transform using genetic programming [PDF]
, 2002 Compression of 2 dimensional data is important for the efficient transmission, storage and manipulation of Images. The most common technique used for lossy image compression relies on fast application of the Discrete Cosine Transform (DCT).
Cui, Xiang Biao, Johnson, Martin
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