Results 41 to 50 of about 3,432,068 (369)
Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum. [PDF]
, 2012 In most organisms, the primary function of homologous recombination (HR) is to allow genome protection by the faithful repair of DNA double-strand breaks.
Buisson, Rémi +9 more
core +2 more sources
PLoS ONE, 2020 Characterizing meiotic recombination rates across the genomes of nonhuman primates is important for understanding the genetics of primate populations, performing genetic analyses of phenotypic variation and reconstructing the evolution of human ...
Cheng Xue +7 more
doaj +1 more source
Competition between recombination and epistasis can cause a transition from allele to genotype selection [PDF]
, 2009 Biochemical and regulatory interactions central to biological networks are expected to cause extensive genetic interactions or epistasis affecting the heritability of complex traits and the distribution of genotypes in populations. However, the inference
Neher, Richard A., Shraiman, Boris I.
core +3 more sources
Genetic Recombination between Human and Animal Parasites Creates Novel Strains of Human Pathogen
PLoS Neglected Tropical Diseases, 2015 Genetic recombination between pathogens derived from humans and livestock has the potential to create novel pathogen strains, highlighted by the influenza pandemic H1N1/09, which was derived from a re-assortment of swine, avian and human influenza A ...
W. Gibson +6 more
semanticscholar +1 more source
An Eco-Evolutionary approach of Adaptation and Recombination in a large population of varying size [PDF]
, 2014 We identify the genetic signature of a selective sweep in a population described by a birth-and-death process with density dependent competition. We study the limit behaviour for large K, where K scales the population size.
Smadi, Charline
core +4 more sources
BMC Genomics, 2015 BackgroundCryptosporidium hominis is a dominant species for human cryptosporidiosis. Within the species, IbA10G2 is the most virulent subtype responsible for all C.
Yaqiong Guo +9 more
semanticscholar +1 more source
Pan-cancer landscape of homologous recombination deficiency
Nature Communications, 2020 Homologous recombination deficiency (HRD) results in impaired double strand break repair and is a frequent driver of tumorigenesis. Here, we develop a genome-wide mutational scar-based pan-cancer Classifier of HOmologous Recombination Deficiency (CHORD ...
Luan Nguyen +3 more
semanticscholar +1 more source
Random-sequence genetic oligomer pools display an innate potential for ligation and recombination
eLife, 2018 Recombination, the exchange of information between different genetic polymer strands, is of fundamental importance in biology for genome maintenance and genetic diversification and is mediated by dedicated recombinase enzymes. Here, we describe an innate
Hannes Mutschler +7 more
doaj +1 more source
Genetics, 2016 Meiotic recombination breaks down linkage disequilibrium (LD) and forms new haplotypes, meaning that it is an important driver of diversity in eukaryotic genomes.
S. Johnston +3 more
semanticscholar +1 more source
Identification and manipulation of the molecular determinants influencing poliovirus recombination.
PLoS Pathogens, 2013 The control and prevention of communicable disease is directly impacted by the genetic mutability of the underlying etiological agents. In the case of RNA viruses, genetic recombination may impact public health by facilitating the generation of new viral
Charles Runckel +3 more
doaj +1 more source