Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Evidence for RNA recombination between distinct isolates of Pepino mosaic virus. [PDF]
, 2010 Genetic recombination plays an important role in the evolution of virus genomes. In this study we analyzed publicly available genomic sequences of Pepino mosaic virus (PepMV) for recombination events using several bioinformatics tools.
Hasiów-Jaroszewska, B. +4 more
core +1 more source
Persistence of two genotypes of Neisseria gonorrhoeae during transmission.
, 2003 Isolates of Neisseria gonorrhoeae were tested using a highly discriminatory typing method, opa typing, to examine the genetic diversity over a 2-year study period of isolates from all consecutive patients with gonorrhea attending the Genitourinary ...
Bell, G +4 more
core +2 more sources
Dynamics of male meiotic recombination frequency during plant development using Fluorescent Tagged Lines in Arabidopsis thaliana [PDF]
, 2017 Meiotic homologous recombination plays a central role in creating genetic variability, making it an essential biological process relevant to evolution and crop breeding.
De Storme, Nico, Geelen, Danny, Li, Fan
core +1 more source
Genetic recombination is directed away from functional genomic elements in mice
Nature, 2012 Genetic recombination occurs during meiosis, the key developmental programme of gametogenesis. Recombination in mammals has been recently linked to the activity of a histone H3 methyltransferase, PR domain containing 9 (PRDM9), the product of the only ...
Kevin Brick +4 more
semanticscholar +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Genetic Recombination in Bacteriophage {varphi}X174 [PDF]
, 1974 Genetic recombination in bacteriophage {varphi}X174 usually takes place early in the infection process and involves two parental replicative form (double-stranded) DNA molecules.
Benbow, Robert M. +3 more
core
The asexual genome of Drosophila
, 2017 The rate of recombination affects the mode of molecular evolution. In high-recombining sequence, the targets of selection are individual genetic loci; under low recombination, selection collectively acts on large, genetically linked genomic segments ...
Lässig, Michael +2 more
core +1 more source
Protocol: Precision engineering of plant gene loci by homologous recombination cloning in Escherichia coli. [PDF]
, 2005 © 2005 Roden et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Göttgens, Berthold +2 more
core +5 more sources
Male recombination map of the autosomal genome in German Holstein
Genetics Selection Evolution, 2020 Background Recombination is a process by which chromosomes are broken and recombine to generate new combinations of alleles, therefore playing a major role in shaping genome variation.
Saber Qanbari, Dörte Wittenburg
doaj +1 more source