Results 61 to 70 of about 681,929 (290)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Genetics solutions for improved chicken production in Ghana

Genetic Resources
The Tropical Poultry Genetics Solutions project intervention in Ghana, a collaboration between the International Livestock Research Institute and the University of Ghana, with support from Ghana’s Ministry of Food and Agriculture, seeks to test the ...
Richard Osei-Amponsah, Ricky Aboagye Poku, Ebenezer Agyemang Duah, Augustine Naazie, Raphael Ayizanga, Harrisson Njamba, Wondmeneh Esatu, Mulugetta Yitayih Birhanu, Tadelle Dessie   +8 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Preserving, improving and rediscovering: The role of the Research Centre of Viticulture and Enology in safeguarding grapevine genetic resources in Italy

Genetic Resources
Grapevine is one the most cultivated species worldwide, with 8,000 estimated varieties. Protecting this biodiversity is of utmost importance, especially in countries historically devoted to viticulture, such as Italy.
Maria Antonietta Palombi, Vittorio Alba, Marco Ammoniaci, Noemi Bevilacqua, Angelo Raffaele Caputo, Roberto Carraro, Stefano Favale, Simone Garavelloni, Massimo Gardiman, Massimo Morassut, Marina Niero, Roberto Nuti, Giuseppina Pipitone, Sergio Puccioni, Alessandra Zombardo   +14 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Combined cytogenetic and molecular methods for taxonomic verification and description of Brassica populations deriving from different origins

Genetic Resources
Agriculture faces great challenges to overcome global warming and improve system sustainability, requiring access to novel genetic diversity. So far, wild populations and local landraces remain poorly explored.
Cyril Falentin, Houria Hadj-Arab, Fella Aissiou, Claudia Bartoli, Giuseppe Bazan, Matéo Boudet, Lydia Bousset-Vaslin, Marwa Chouikhi, Olivier Coriton, Gwénaelle Deniot, Julie Ferreira de Carvalho, Laurène Gay, Anna Geraci, Pascal Glory, Virginie Huteau, Riadh Ilahy, Vincenzo Ilardi, José A. Jarillo, Vladimir Meglic, Elisabetta Oddo, Monica Pernas, Manuel Pineiro, Barbara Pipan, Thouraya Rhim, Vincent Richer, Fulvia Rizza, Joelle Ronfort, Mathieu Rousseau-Gueutin, Rosario Schicchi, Lovro Sinkovic, Maryse Taburel, Valeria Terzi, Sylvain Théréné, Mathieu Tiret, Imen Tlili, Marie-Hélène Wagner, Franz Werner Badeck, Anne-Marie Chèvre   +37 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Genetic divergence study on growth, yield and quality traits in pink brinjal (Solanum melongena L.) in the subtropical plains of Jammu, India

Genetic Resources
In 2022, field investigation was conducted to examine the genetic diversity among 30 pink brinjal (eggplant, Solanum melongena L.) genotypes originating from India. Mahalanobis D2 analysis was performed to analyze the data for eighteen growth, yield and
Vishwash Bandhral, Anil Bhushan, Ravinder Kumar Samnotra, Sonali Sharma, Diksha Rani   +4 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source