Results 71 to 80 of about 7,107,321 (247)

Genetic divergence study on growth, yield and quality traits in pink brinjal (Solanum melongena L.) in the subtropical plains of Jammu, India

Genetic Resources
In 2022, field investigation was conducted to examine the genetic diversity among 30 pink brinjal (eggplant, Solanum melongena L.) genotypes originating from India. Mahalanobis D2 analysis was performed to analyze the data for eighteen growth, yield and
Vishwash Bandhral, Anil Bhushan, Ravinder Kumar Samnotra, Sonali Sharma, Diksha Rani   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Carp genetic resources for aquaculture in Asia [PDF]

There are over 1 300 species of cyprinids in Asia, which form an important part of the worldÆs aquatic biodiversity. Aquaculture and capture fisheries involving cyprinids are a vital part of the livelihoods of many millions of people in this region. The
Gupta, M.V., Penman, D.J., Dey, M.M. (eds)   +2 more
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Survey on threatened medicinal plants diversity of Northwestern Syria

Genetic Resources
Throughout history, many plant species have been used as natural medicines to prevent and treat human diseases. Due to its geographical location, climate, and history, Syria contains a remarkable diversity of medicinal plants. However, in recent years a
Munzer Aldarvish, Anas Al Kaddour, Akram Bourgol, Yasser Ramazan, Yousef Hallak, Stephen Cavers , Joan Cottrell   +6 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The Versailles Arabidopsis Stock Center (VASC): original genetic resources exploiting both induced and natural diversity to investigate gene functions and analyze the impact of variation on plant biology

Genetic Resources
Arabidopsis thaliana is a powerful plant model for functional biology, genetics and, more recently, population genomics. The Versailles Arabidopsis Stock Center collects, produces, preserves, characterizes and distributes various Arabidopsis biological ...
Anthony Ricou, Carine Géry, Christine Horlow, Olivier Loudet, Christine Camilleri   +4 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Report of the First Meeting of the CGIAR Genetic Resources Policy Committee

, 1995
The CGIAR Genetic Resources Policy Committee (GRPC) held its first meeting in Madras in January 1995, under the chairmanship of M.S. Swaminathan. The committee reviewed and accepted its terms of reference, found in Annex 3.
CGIAR Committee on Genetic Resources
core   +1 more source