Results 61 to 70 of about 7,107,321 (247)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

International Plant Genetic Resources Institute (IPGRI): Financial Statements for December 31, 2003 with Independent Auditor's Report

open access: yes, 2004
Independent auditor's report for IPGRI's financial statements as of December 31, 2003 and statements of activity, statements of assets, and cash flows.
International Plant Genetic Resources Institute
core   +1 more source

Genetics solutions for improved chicken production in Ghana

open access: yesGenetic Resources
The Tropical Poultry Genetics Solutions project intervention in Ghana, a collaboration between the International Livestock Research Institute and the University of Ghana, with support from Ghana’s Ministry of Food and Agriculture, seeks to test the ...
Richard Osei-Amponsah   +8 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

Preserving, improving and rediscovering: The role of the Research Centre of Viticulture and Enology in safeguarding grapevine genetic resources in Italy

open access: yesGenetic Resources
Grapevine is one the most cultivated species worldwide, with 8,000 estimated varieties. Protecting this biodiversity is of utmost importance, especially in countries historically devoted to viticulture, such as Italy.
Maria Antonietta Palombi   +14 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Combined cytogenetic and molecular methods for taxonomic verification and description of Brassica populations deriving from different origins

open access: yesGenetic Resources
Agriculture faces great challenges to overcome global warming and improve system sustainability, requiring access to novel genetic diversity. So far, wild populations and local landraces remain poorly explored.
Cyril Falentin   +37 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

SGRP Annual Report 2006: Of the CGIAR System-wide Genetic Resources Programme

open access: yes, 2019
The System-wide Genetic Resources Programme (SGRP) unites all of the independent centres of the Consultative Group on International Agricultural Research (CGIAR) in a collaborative effort to sustain biodiversity for current and future generations.
CGIAR Systemwide Genetic Resources Programme
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Home - About - Disclaimer - Privacy