Results 91 to 100 of about 7,107,321 (247)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
A small-scale assessment of the availability of EURISCO accessions
Genetic ResourcesA critical assessment of plant genetic resource (PGR) availability in Europe reveals a significant gap between documented accessions and those that are practically obtainable for researchers and breeders.
Erik Wijnker, Theo van Hintum
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
, 2006 Independent auditor's report for IPGRI's financial statements as of December 31, 2005 and 2004 and statements of activity, statements of assets, and cash flows.
International Plant Genetic Resources Institute
core +1 more source
Rose genetic resources conserved ex situ at the M.M. Gryshko National Botanical Garden, Ukraine
Genetic ResourcesThe rose genetic collection of the M.M. Gryshko National Botanical Garden, National Academy of Sciences of Ukraine (Kyiv, Ukraine) is the largest and most systematically studied Rosa collection in the country.
Olena Rubtsova +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Optimal Search in Ex situ Collections of Wheat Genetic Resources [PDF]
This paper develops a theoretical model for analyzing gene bank management decisions regarding the search for traits of economic value in ex situ collections of wheat.
Gollin, Douglas +2 more
core
Expanding the genetic diversity of chickpeas from the Ukrainian genebank to new agricultural systems
Genetic ResourcesEnhancing crop resilience to abiotic factors in an increasingly unstable climate is a critical challenge, one that can be met by actively using the existing gene pool of the crops.
Nadiia Vus +6 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Genetic ResourcesSustainable breeding of native breeds is essential to preserve genetic diversity and cultural heritage. Several native Nordic horse breeds are at risk of extinction and lack genetic characterization.
Nathalie Smogeli +9 more
doaj +1 more source