Results 101 to 110 of about 7,107,321 (247)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Report of the Twelfth Meeting of the CGIAR Genetic Resources Policy Research Committee

open access: yes, 2001
Report of the twelfth meeting of the CGIAR Genetic Resources Policy Committee (GRPC), held in Aurangabad, India from February 20 to 23, 2001, Committee Chair M.S. Swaminathan presiding.
CGIAR Genetic Resources Policy Committee
core   +1 more source

Characterization of Iranian rice genetic resources for key grain quality traits

open access: yesGenetic Resources
Grain quality traits are crucial for rice (Oryza sativa L.) breeding, as they significantly influence consumer preferences and market value. This study evaluated 48 diverse rice genotypes, including a strong representation of Iranian landraces that ...
Mostafa Modarresi
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

Selection of a core collection from the US castor bean germplasm collection

open access: yesGenetic Resources
Castor bean (Ricinus communis L.) is a medicinal, industrial and biodiesel crop that is adapted to marginal soils in hot, dry and semi-arid environments, but its genetic potential is not fully exploited. Genetic variation exists in different castor bean
Brad Morris   +3 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

The EURISCO-EVA Information System, an innovative approach to the data management of multi-site crop evaluation data

open access: yesGenetic Resources
This paper introduces EURISCO-EVA, an extension of the European Search Catalogue for Plant Genetic Resources (EURISCO) hosted at and maintained by IPK Gatersleben on behalf of the European Cooperative Programme for Plant Genetic Resources (ECPGR).
Suman Kumar   +3 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

SGRP annual report 2004/2005: Of the CGIAR System-wide Genetic Resources Programme

open access: yes, 2019
SGRP seeks to improve the effectiveness of the CGIAR System in managing genetic resources as global public goods, including the delivery of research, knowledge and capacity-development.
CGIAR Systemwide Genetic Resources Programme
core   +1 more source

A case study on lentil to demonstrate the value of using historic data stored in genebanks to guide the selection of resources for research and development projects

open access: yesGenetic Resources
Plant genetic resources are essential for sustainable agriculture and a secure and stable global food supply. One of the most important pulses and an integral part of a healthy diet is lentil (Lens culinaris Medik.).
Nadiia Vus   +7 more
doaj   +1 more source

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