Results 11 to 20 of about 8,942,317 (309)

Genetic risk in Alzheimer’s disease [PDF]

npj Systems Biology and Applications
Alzheimer's disease (AD) has a strong genetic predisposition. Genome-wide association studies have identified multiple risk loci, yet many non-coding variants remain uncharacterized. Machine learning-based polygenic risk scores (PRS) enhance prediction by modeling genetic epistasis and sex-specific risks. This review summarizes AD genetic risk factors,
Pan, Yining, Cho, Hwayoung, Lou, Qian, Zhang, Wei, Asken, Breton, Song, Qianqian   +5 more
openaire   +4 more sources

Public Awareness of Genetic Influence on Chronic Disease Risk: Are Genetic and Lifestyle Causal Beliefs Compatible? [PDF]

, 2010
Background/Aims: There is concern that raising awareness about the role of genetics in chronic disease etiology could undermine public belief that lifestyles are important, leading to adverse effects on public health. We tested the hypothesis that people
Sanderson, SC, Waller, J, Humphries, SE, Wardle, J, Jane Wardle, Jo Waller, Steve E. Humphries, Saskia C. Sanderson   +7 more
core   +1 more source

Male awareness of prostate cancer risk remains poor in relatives of women with germline variants in DNA‐repair genes

BJUI Compass, 2023
Abstract Objective The aim of this study is to evaluate male awareness of developing prostate cancer (PCa) in families with germline DNA‐repair genes (DRG) variants.
Vittorio Fasulo, NicolòMaria Buffi, Giuseppe Chiarelli, Giovanni Lughezzani, Monica Zuradelli, Carla Barbara Ripamonti, Monica Barile, Paolo Bianchi, Alessio Benetti, Marco Paciotti, Alessandro Uleri, Pier Paolo Avolio, Alberto Saita, Rodolfo Hurle, Federica Maura, Luca Germagnoli, Rosanna Asselta, Giulia Soldà, Paolo Casale, Massimo Lazzeri   +19 more
doaj   +1 more source

Alpha-1 antitrypsin Pi∗Z allele is an independent risk factor for liver transplantation and death in patients with advanced chronic liver disease

JHEP Reports, 2022
Background & Aims: Alpha-1 antitrypsin (AAT) deficiency causes/predisposes individuals to advanced chronic liver disease (ACLD). However, the role of the SERPINA1 Pi∗Z allele in patients who have already progressed to ACLD is unclear.
Lorenz Balcar, Bernhard Scheiner, Markus Urheu, Patrick Weinberger, Rafael Paternostro, Benedikt Simbrunner, Lukas Hartl, Mathias Jachs, David Bauer, Georg Semmler, Claudia Willheim, Matthias Pinter, Peter Ferenci, Michael Trauner, Thomas Reiberger, Albert Friedrich Stättermayer, Mattias Mandorfer   +16 more
doaj   +1 more source

Genetic Risk Scores

Current Protocols in Human Genetics, 2019
AbstractGenome‐wide variation data with millions of genetic markers have become commonplace. However, the potential for interpretation and application of these data for clinical assessment of outcomes of interest, and prediction of disease risk, is currently not fully realized.
Robert P, Igo, Tyler G, Kinzy, Jessica N, Cooke Bailey   +2 more
openaire   +3 more sources

Genetic Relationship Between Endometriosis and Melanoma

Frontiers in Reproductive Health, 2021
Epidemiological studies have observed that risk of endometriosis is associated with history of cutaneous melanoma and vice versa. Evidence for shared biological mechanisms between the two traits is limited.
Fei Yang, Sally Mortlock, Stuart MacGregor, Mark M. Iles, Mark M. Iles, Maria Teresa Landi, Jianxin Shi, Matthew H. Law, Matthew H. Law, Grant W. Montgomery   +9 more
doaj   +1 more source

Genetic risk variants in intestinal inflammatory disorders [PDF]

, 2010
PhDThis thesis includes work on the genetics of intestinal inflammatory disorders, concentrating on coeliac disease and Crohn’s disease. It explores how common genetic variants influence risk of complex phenotypes including immunological intolerance to
Dubois, Patrick Charles Alexander
core   +2 more sources

No Evidence of Association between Childhood Urban Environment and Cortical Thinning in Psychotic Disorder.

PLoS ONE, 2017
BackgroundThe alterations in cortical morphology, such as cortical thinning, observed in psychotic disorder, may be the outcome of interacting genetic and environmental effects.
Aleida Frissen, Jim van Os, Petra Habets, Ed Gronenschild, Machteld Marcelis, Genetic Risk and Outcome in Psychosis (G.R.O.U.P.)   +5 more
doaj   +1 more source

Genetic Risk Assessment [PDF]

JAPCA, 1987
Assessing human risk to mutagenic substances represents a formidable task. There has been no conclusive evidence supporting chemical-induced mutation in human germ cells; however, mutagens are detected in rodent germ cells using a limited number of assays including the mouse specific locus assay and the heritable translocation assay.
openaire   +2 more sources

DNA methylation mediated genetic risk in severe acne in a young men population

Frontiers in Medicine, 2023
BackgroundAcne is a chronic inflammatory skin disease that affects the pilosebaceous follicle and is influenced by heredity, hormones, inflammation, and the environment.
Yujia Wu, Yun Chen, Bo Chen, Wenjuan Wu, Jiankang Yang   +4 more
doaj   +1 more source