Results 41 to 50 of about 8,942,317 (309)
Genetic risks and clinical rewards [PDF]
Nature Genetics, 2018 Individual genome-wide polygenic risk scores (GPSs) for assessing disease susceptibility have been shown to yield both reliable and clinically meaningful results. However, certain impediments and outdated ways of thinking about health maintenance must be overcome before GPSs are adopted in routine care streams.
Andrew J, Schork +2 more
openaire +2 more sources
Prospective genetic screening decreases the incidence of Abacavir hypersensitivity reactions in the Western Australian HIV cohort study [PDF]
, 2005 Abacavir therapy is associated with significant drug hypersensitivity in ∼8% of recipients, with retrospective studies indicating a strong genetic association with the HLA-B*5701 allelle.
McKinnon, E. +11 more
core +2 more sources
Hypercholesterolemia in the Malaysian Cohort Participants: Genetic and Non-Genetic Risk Factors
, 2023 Hypercholesterolemia was prevalent in 44.9% of The Malaysian Cohort participants, of which 51% were Malay. This study aimed to identify the variants involved in hypercholesterolemia among Malays and to determine the association between genetic and non ...
Rahman Jamal +11 more
core +1 more source
South African Medical Journal, 2016 Prof. Peter Beighton has given a professional lifetime to helping patients and their families who have been afflicted by inherited disease. His clinical skills have brought certainty, confidence and support to those confronted with some of the most difficult decisions in life's progress. Prof.
openaire +6 more sources
Nutrition, Genetics, and Risks of Cancer [PDF]
Annual Review of Public Health, 2000 ▪ Abstract Dietary patterns, nutrients, and other constituents of food are major components of the environmental influences that contribute to risk for cancer, and the study of interactions between nutritional and genetic factors is a new and important area of research.
C L, Rock, J W, Lampe, R E, Patterson
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld +5 more
wiley +1 more source
Pervasive Sharing of Genetic Effects in Autoimmune Disease [PDF]
, 2011 Genome-wide association (GWA) studies have identified numerous, replicable, genetic associations between common single nucleotide polymorphisms (SNPs) and risk of common autoimmune and inflammatory (immune-mediated) diseases, some of which are shared ...
Klareskog, Lars +113 more
core +1 more source
Physical Activity and Brain Function in Older Adults at Increased Risk for Alzheimer’s Disease
Brain Sciences, 2013 Leisure-time physical activity (PA) and exercise training are known to help maintain cognitive function in healthy older adults. However, relatively little is known about the effects of PA on cognitive function or brain function in those at increased ...
Stephen M. Rao +4 more
doaj +1 more source
Germline Genetic Risk Variants for Progressive Multifocal Leukoencephalopathy
Frontiers in Neurology, 2020 Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disorder of the brain caused by reactivation of the JC virus (JCV), a polyomavirus that infects at least 60% of the population but is asymptomatic or results in benign symptoms in ...
Peggy S. Eis +11 more
doaj +1 more source
Clinical & Translational Immunology, 2021 Objectives It remains unknown how inflammatory marker levels differ amongst individuals susceptible to coronavirus disease 2019 (COVID‐19), prior to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and the onset of the cytokine ...
Timothy R Powell +5 more
doaj +1 more source