Results 71 to 80 of about 8,942,317 (309)

Genetic-Based Prediction of Disease Traits: Prediction is Very Difficult, Especially about the Future

Frontiers in Genetics, 2014
Translation of results from genetic findings to inform medical practice is a highly anticipated goal of human genetics. The aim of this paper is to review and discuss the role of genetics in medically-relevant prediction.
Steven J Schrodi, Shubhabrata eMukherjee, Ying eShan, Gerard eTromp, John J Sninsky, Amy P Callear, Amy P Callear, Tonia C. Carter, Zhan eYe, Jonathan L Haines, Murray H Brilliant, Paul K Crane, Diane T Smelser, Robert C Elston, Daniel E Weeks   +14 more
doaj   +1 more source

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz   +8 more
wiley   +1 more source

Association of life's essential 8 and genetic predisposition with the risk of osteoarthritis: a prospective cohort study

Frontiers in Nutrition
BackgroundOsteoarthritis (OA) is a prevalent joint disorder with significant health and economic impacts. While individual cardiovascular health (CVH) factors have been linked to OA, a comprehensive understanding of how overall cardiovascular health ...
Changyu Du, Changyu Du, Tingting Zhou, Tingting Zhou, Xiang Ji, Xiang Ji, Xiaofu Tang, Honghao Yang, Honghao Yang, Zheng Ma, Zheng Ma, Mingjie Kuang, Liangkai Chen, Xiaofeng Li, Xiaofeng Li, Hongfei Wang, Chengrui Yang, Xiaoming Li, Xiaoming Li, Jianyong Zhao, Jianyong Zhao, Yang Xia, Yang Xia   +22 more
doaj   +1 more source

The DREAM BIG project as a model for harmonizing early measures of parental care and parent-child interactions across epidemiological cohorts

Frontiers in Child and Adolescent Psychiatry, 2023
Parenting is a key contributor to child development. The effects of parenting, however, also depend on child characteristics, including genetic factors. A more complete appraisal of the role of parenting thus requires a comprehensive developmental model ...
Eszter Szekely, Eszter Szekely, David P. Laplante, Henning Tiemeier, Henning Tiemeier, Jonathan Evans, Rebecca M. Pearson, Rebecca M. Pearson, Mona Bekkhus, Marian Bakermans-Kranenburg, Marinus H. van IJzendoorn, Marinus H. van IJzendoorn, Ashley Wazana, Ashley Wazana   +13 more
doaj   +1 more source

Genetic combination risk for schizophrenia [PDF]

Schizophrenia Research, 2018
Summary Paragraph Schizophrenia is a highly hereditary mental disease 1 related to abnormal dopaminergic activities. 2,3 To elucidate the mechanisms underlying schizophrenia’s development, genomic studies have sought to identify the pathogenic ...
Oishi, Kengo, Niitsu, Tomihisa, Kanahara, Nobuhisa, Hashimoto, Tasuku, Komatsu, Hideki, Sasaki, Tsuyoshi, Takase, Masayuki, Sato, Yasunori, Iyo, Masaomi   +8 more
openaire   +2 more sources

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

Ecological modernization versus sustainable development: the case of genetic modification regulation in New Zealand [PDF]

, 2009
Ecological modernization and sustainable development are the two dominant paradigms in environmental policy. This paper assesses the implications of competing understandings of ecological modernization and sustainable development using the case of ...
Wright, Jeanette Marie, Priya Kurian, Jeanette Wright, Kurian, Priya A.   +3 more
core   +1 more source

Genetic Risk Profiling Associated with Recurrent Unprovoked Venous Thromboembolism

, 2021
Introduction: Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and/or pulmonary embolism (PE), is a common, acute, multifactorial disease with a five-years cumulative incidence of recurrence of approximately 25%.
Ola A. ELshora, Mohammed F. Abosamak, Amira Youssef, Ahmed Esam, Hossam Hodeib, Mohamed A. Tawfik, Mohamed S. Abd Elghafar, Sameh Samir, Amal Selim, Alzahraa A. Allam   +9 more
core   +1 more source

GBA1 Gene-Associated Transcriptomic Signatures Reveal Risk Genes in Parkinson’s Disease

Biomedicines
Background/Objectives: Pathogenic variants in the GBA1 gene, which encodes the lysosomal enzyme β-glucocerebrosidase, cause Gaucher disease (GD) and represent one of the strongest genetic risk factors for Parkinson’s disease (PD).
Yanjun Liu, Xi Luo, Ronan M. T. Fleming
doaj   +1 more source

The interaction between smoking and bladder cancer genetic variants on urothelial cancer risk by disease aggressiveness

Cancer Medicine, 2022
Background Smoking has shown interactions with bladder cancer (BC) genetic variants, especially N‐acetyltransferase‐2 (NAT2), a tobacco smoke metabolism gene, on BC risk. The interactions by disease aggressiveness are unknown. Methods We investigated the
Stanley Teleka, Sylvia H. J. Jochems, Karin Jirström, Tanja Stocks   +3 more
doaj   +1 more source