Results 121 to 130 of about 5,319,582 (307)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Genetic aspects of feed intake in lactating sows [PDF]
, 2011 Productivity of sows has increased worldwide, especially during the last decade. Sows have been changed genetically to produce larger litters. It was hypothesized that including feed intake or feed efficiency during lactation or both in the breeding ...
Bergsma, R.
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Frontiers in Sustainable Food SystemsThe Arganeraie ecosystem (Argania spinosa L. Skeels), a key ecological, cultural, and socio-economic pillar of Morocco’s Anti-Atlas Mountains and a UNESCO Biosphere Reserve, is facing severe decline characterized by rising mortality and the failure of ...
Zoulfa Roussi +4 more
doaj +1 more source
Genetic Prediction and Adverse Selection
EconometricaRecent advances have substantially improved our ability to predict disease risk with genetic data. In response, many countries have banned insurers from using genetic data, despite concerns about adverse selection. This paper measures adverse selection in a market where insurers can underwrite only on nongenetic information while consumers also have ...
Eduardo Azevedo +2 more
openaire +1 more source
Model-Based Problem Solving through Symbolic Regression via Pareto Genetic Programming. [PDF]
Pareto genetic programming methodology is extended by additional generic model selection and generation strategies that (1) drive the modeling engine to creation of models of reduced non-linearity and increased generalization capabilities, and (2 ...
Vladislavleva, E.
core
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Open Veterinary JournalBackground: The selection of sheep with high genetic resistance to gastrointestinal nematodes is a sustainable alternative for parasite control. Aim: This study was performed to categorize three breeds of hair sheep according to their resistance to ...
María Guadalupe Pulido López +6 more
doaj +1 more source
A Genetical Theory of Species Selection
Journal of Theoretical Biology, 1995 Species selection, differential rates of speciation or extinction resulting from species level characters, is often invoked as the main mechanism of macroevolution that is not simply an extension of microevolutionary processes. So long as we are careful in defining "species", the logic of species selection is sound.
openaire +2 more sources