Results 101 to 110 of about 2,212,354 (298)
Fertility selection, genetic selection and evolution [PDF]
Journal of Evolutionary Biology, 2000 Abstract The relationship between fertility selection as measured by the correlation in progeny number between parents and offspring, and selection at individual loci is investigated in humans. Estimates for the magnitude of fertility selection (0.1) and the rate of gene substitution (0.5 gene substitutions per generation per genome) are
openaire +1 more source
Efficient inference for genetic association studies with multiple outcomes
, 2017 Combined inference for heterogeneous high-dimensional data is critical in modern biology, where clinical and various kinds of molecular data may be available from a single study.
Davison, Anthony C. +3 more
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Modern approaches for breeding high quality apples with durable resistance to scab, powdery mildew and fire blight [PDF]
, 2008 New methods to allow for more precise selection of tree and fruit characters in breeding programmes were developed in recent years. Marker-assisted selection (MAS) is common practice in the ACW apple breeding programme at Wädenswil.
Duffy, Brion +3 more
core
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Host Genetics and the Skin Microbiome Independently Predict Parasite Resistance
Ecology and EvolutionHost responses to parasite infection involve several interacting systems. Host genetics determine much of the response, but it is increasingly clear that the host‐associated microbiome also plays a role.
Rachael D. Kramp +5 more
doaj +1 more source
World Rabbit Science, 2013 In the present work is analysed how frequent feeding and selection programmes could be affecting resources allocation in reproductive rabbit does, and the possible consequences resulted from these changes, as well as the central role of body condition ...
Juan José Pascual +3 more
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Liver metabolism traits in two rabbit lines divergently selected for intramuscular fat
Animal, 2018 Intramuscular fat (IMF) has a large effect in the sensory properties of meat because it affects tenderness, juiciness and flavour. A divergent selection experiment for IMF in longissimus dorsi (LD) muscle was performed in rabbits.
M. Martínez-Álvaro +4 more
doaj +1 more source