Results 111 to 120 of about 5,319,582 (307)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Host Genetics and the Skin Microbiome Independently Predict Parasite Resistance

Ecology and Evolution
Host responses to parasite infection involve several interacting systems. Host genetics determine much of the response, but it is increasingly clear that the host‐associated microbiome also plays a role.
Rachael D. Kramp, Mary J. Janecka, Nadine Tardent, Jukka Jokela, Kevin D. Kohl, Jessica F. Stephenson   +5 more
doaj   +1 more source

The prospects of selection for social genetic effects to improve welfare and productivity in livestock

Frontiers in Genetics, 2014
Social interactions between individuals living in a group can have both positive and negative effects on welfare, productivity, and health of these individuals.
Esther D. Ellen, T. Bas Rodenburg, Gerard A.A. Albers, J. Elizabeth Bolhuis, Irene eCamerlink, Irene eCamerlink, Naomi eDuijvesteijn, Naomi eDuijvesteijn, Egbert F. Knol, William M. Muir, Katrijn ePeeters, Katrijn ePeeters, Inonge eReimert, Ewa eSell-Kubiak, Johan A.M. Van Arendonk, Jeroen eVisscher, Piter eBijma   +16 more
doaj   +1 more source

Genetic linkage and natural selection [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2010
Abstract The prevalence of recombination in eukaryotes poses one of the most puzzling questions in biology. The most compelling general explanation is that recombination facilitates selection by breaking down the negative associations generated by random drift (i.e. Hill–Robertson interference, HRI).
openaire   +2 more sources

Genetic variability under step-wise discrete mutation and stabilizing selection

, 1992
To explain the nature of genetic variability for quantitative traits in infinitely large natural populations, a model involving step-wise mutation with discrete allelic effects and stabilizing selection of optimal type is considered.
Narain, P.
core  

Genetic tools for studying adaptation and the evolution of behavior [PDF]

, 2002
C.R.B.B. acknowledges support from the National Science Foundation (NSF; grants IBN‐0086955 and IBN‐0120394), which funded the workshops and symposium that produced this article. A.J.M. and M.G.R.
Ritchie, M G, Moore, A J, Taylor, B J, Wolf, J B, Breden, F, Boake, C R B, Meffert, L M, Arnold, S J, Boake, Christine R B, Arnold, Stevan J., Taylor, Barbara J., Ritchie, Michael G., Breden, Felix, Moore, Allen J., Wolf, Jason B., Meffert, Lisa M., Ritchie, M G ; id_orcid   +16 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Body conformation and robustness as potential frontiers in pasture-based beef cattle breeding: a narrative review

Frontiers in Animal Science
As the demand for pasture-finished beef continues to grow, the importance of sustainably producing cattle under pasture-based systems has become increasingly evident.
Titus J. Zindove
doaj   +1 more source

SNP genotyping identifies new signatures of selection in a deep sample of West African Plasmodium falciparum malaria parasites. [PDF]

, 2012
We used a high-density single-nucleotide polymorphism array to genotype 75 Plasmodium falciparum isolates recently collected from Senegal and The Gambia to search for signals of selection in this malaria endemic region.
Bei, Amy K, Conway, David J, Ndiaye, Daouda, Schaffner, Stephen, Neafsey, Daniel E, Wirth, Dyann, Lukens, Amanda, Conway, David J., Park, Daniel J, Volkman, Sarah, Amambua-Ngwa, Alfred, Wirth, Dyann F, Barnes, Kayla G., Schaffner, Stephen F, Lukens, Amanda K, Park, Daniel John, Bei, Amy, Van Tyne, Daria, Volkman, Sarah K, Sene, Papa, Neafsey, Daniel, Barnes, Kayla G   +21 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source