Results 171 to 180 of about 1,247,014 (268)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Coral Genetic Structure in the Western Indian Ocean Mirrors Ocean Circulation and Thermal Stress History. [PDF]

Evol Appl
Guillaume AS, Joost S, Curpen S, Dumur Neelayya D, Harree-Somah L, Sadasing O, Saponari L, Dale C, Barret L, Andrews N, Leckraz SK, François R, Seetapah V, Munusami V, Bacha Gian S, Jhangeer-Khan R, Mahoune T, Chumun PK, Poretti M, Berteaux-Lecellier V, Lecellier G, Selmoni O.   +21 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Uncovering the Genetic Structure of European Anchovy Populations in Central and Western Mediterranean. [PDF]

Ecol Evol
Alexandridis D, Manousaki T, Antoniou A, Kristoffersen J, Apostolidis C, Cannas R, Spedicato MT, Cariani A, Bellido JM, Magoulas A, Ramírez F, Lloret-Lloret E, Albo-Puigserver M, Coll M, Tsigenopoulos CS.   +14 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Glacial History and Landscape Features Shape the Hierarchical Population Genetic Structure of Woodland Caribou (<i>Rangifer tarandus caribou</i>) in Western Canada. [PDF]

Evol Appl
Deakin S, Michalak A, Cavedon M, Bourbon C, Hughes MM, Neufeld L, Pelletier A, Polfus J, Schwantje H, Steenweg R, Thacker C, Trottier M, Musiani M, Poissant J.   +13 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Paternal genetic structure and Y-chromosomal haplogroup prediction in the Tujia and Bai ethnic groups of Guizhou, Western China. [PDF]

BMC Genomics
Wang W, Zhen X, Zhang H, Zhao J, An N, Ding J, Qi P, Yang M.   +7 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Integrated molecular and phenotypic analysis of onion (<i>Allium cepa</i> L.) germplasm reveals limited correspondence between genetic structure and phenotypic traits. [PDF]

Front Plant Sci
Sinkovič L, Tavakoli Hasanaklou H, Karče Poljanšek N, Šuštar Vozlič J, Pipan B.   +4 more
europepmc   +1 more source