Results 171 to 180 of about 10,428,446 (310)

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Genetic Structure and Signs of Local Adaptation in Icelandic Brown Trout Populations. [PDF]

Ecol Evol
Lagunas M, Pálsson A, Jerman-Plesec L, Jónsson ZO, Snorrason SS.   +4 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Deciphering centuries of selection: genetic structure and reproductive screening in Basilicata and Calabria's ancient olives. [PDF]

Front Plant Sci
Mariotti R, Carriero F, Vatrano T, Lacertosa G, Nikbakht R, Bashir MA, Cruciani L, Mousavi S.   +7 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Clonality, management and geography shape genetic structure in a perennial species with restricted distribution. [PDF]

Ann Bot
Martínez-Velasco I, Gasca-Pineda J, Mastretta-Yanes A, Gargiulo R, Klimova A, Aguirre-Planter E, Valiente-Banuet A, Lira R, Eguiarte LE.   +8 more
europepmc   +1 more source

Environmental and genetic factors influencing biofilm structure

, 2000
It is increasingly evident that biofilms growing in a diverse range of medical, industrial, and natural environments form a similarly diverse range of complex structures (Stoodley et al., 1999a).
Lappin-Scott, H.M., Jorgensen, F., Boyle, J.D., Stoodley, P., Hall-Stoodley, Luanne   +4 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

An Exploratory Analysis of Genetic Structure and Introgression in <i>Salmo trutta</i> Populations from Campania Rivers. [PDF]

Animals (Basel)
Montone AMI, Fulgione A, Cutarelli A, Gentile A, Brunetti R, Serpe FP.   +5 more
europepmc   +1 more source