Results 201 to 210 of about 1,292,797 (268)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Maternal genetic structure and population affinities of the Sichuan Han Chinese based on whole mitochondrial genomes. [PDF]

BMC Genomics
Jiang X, Chen C, Zhao M, Hu L, Shi L, Tang T, Lv B, Ji S, Jia L, Pang J, Ma J, Mu B, Yang J.   +12 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Fine-Scale Spatial Genetic Structure and Leaf Shape Variation in Five Fagaceae Species: Insights Into Conservation and Adaptation. [PDF]

Ecol Evol
Wang R, Luo Y, Qi M, Zhang Y, Zhang J, Luo Y, Du FK.   +6 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Coral Genetic Structure in the Western Indian Ocean Mirrors Ocean Circulation and Thermal Stress History. [PDF]

Evol Appl
Guillaume AS, Joost S, Curpen S, Dumur Neelayya D, Harree-Somah L, Sadasing O, Saponari L, Dale C, Barret L, Andrews N, Leckraz SK, François R, Seetapah V, Munusami V, Bacha Gian S, Jhangeer-Khan R, Mahoune T, Chumun PK, Poretti M, Berteaux-Lecellier V, Lecellier G, Selmoni O.   +21 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Genetic structure and admixture of the Yi and Qiang in southwestern China. [PDF]

J Zhejiang Univ Sci B
Liu J, Jiang L, Kong Y, Wang C, Feng S, Chen X, Zhang D, Wang C, Li C.   +8 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Uncovering the Genetic Structure of European Anchovy Populations in Central and Western Mediterranean. [PDF]

Ecol Evol
Alexandridis D, Manousaki T, Antoniou A, Kristoffersen J, Apostolidis C, Cannas R, Spedicato MT, Cariani A, Bellido JM, Magoulas A, Ramírez F, Lloret-Lloret E, Albo-Puigserver M, Coll M, Tsigenopoulos CS.   +14 more
europepmc   +1 more source