Results 241 to 250 of about 2,690,236 (305)

Mutation in the knockdown resistance gene and population genetic structure in Culex tritaeniorhynchus from Guizhou Province. [PDF]

Parasit Vectors
Li W, Liu Z, Tang X, Liu C, Wang L, Deng K, Liu L, Wu J.   +7 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Origin, evolution, dispersal and global population genetic structure of <i>Carlavirus sigmasolani</i>. [PDF]

Front Plant Sci
Lei J, Liang B, Yang H, Zhang B.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A preliminary assessment of population genetic structure of the common vampire bat (<i>Desmodus rotundus</i>) in Colombia. [PDF]

PeerJ
Van de Vuurst P, Cifuentes-Rincon A, Bertke AS, Soler-Tovar D, Reyes-Amaya N, Rodriguez Arévalo F, Cárdenas Hincapié JS, Rivera-Monroy J, Escobar LE, Hallerman E.   +9 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Genetic structure analysis of a Northwest Chinese population using a self-developed DIP system and machine learning for forensic ancestry inference. [PDF]

BMC Genomics
Cai M, Shen R, Shi X, Wu Y, Luo L, Liang Q, Zhu B.   +6 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Genetic structure of different ethnic populations at the frontotemporal dementia risk loci. [PDF]

PLoS One
Mavrych V, Alamil M, Bolgova O, Dvornyk V.   +3 more
europepmc   +1 more source

Genetic Diversity and Population Genetic Structure of Endemic Schizothoracinae Fishes in the Upper Yellow River and Its Adjacent Waters. [PDF]

Ecol Evol
Feng X, Wang X, Zhu R, Jia Y, Sui X, Zhuo Y, Li J, Chen Y.   +7 more
europepmc   +1 more source