Results 51 to 60 of about 1,292,797 (268)

The Genetic Structure of the Swedish Population

PLoS ONE, 2011
Patterns of genetic diversity have previously been shown to mirror geography on a global scale and within continents and individual countries. Using genome-wide SNP data on 5174 Swedes with extensive geographical coverage, we analyzed the genetic structure of the Swedish population.
Humphreys K, Grankvist A, Leu M, Hall P, Liu J, Ripatti S, Rehnström K, Groop L, Klareskog L, Ding B, Grönberg H, Xu J, Pedersen NL, Lichtenstein P, Mattingsdal M, Andreassen OA, O'Dushlaine C, Purcell SM, Sklar P, Sullivan PF, Hultman CM, Palmgren J, Magnusson PK   +22 more
openaire   +6 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Analysis of Genetic Diversity and Structure of Eight Populations of Nerita yoldii along the Coast of China Based on Mitochondrial COI Gene

Animals
Nerita yoldii is a euryhaline species commonly found in the intertidal zone. To investigate the genetic diversity of 233 N. yoldii individuals from eight locations along the coast of China, we utilized the mitochondrial COI gene as a molecular marker.
Senping Jiang, Zhenhua Li, Jiji Li, Kaida Xu, Yingying Ye   +4 more
doaj   +1 more source

Lack of conspicuous sex‐biased dispersal patterns at different spatial scales in an Asian endemic goose species breeding in unpredictable steppe wetlands

Ecology and Evolution, 2020
Dispersal affects the spatial distribution and population structure of species. Dispersal is often male‐biased in mammals while female‐biased in birds, with the notable exception of the Anatidae.
Qin Zhu, Iderbat Damba, Qingshan Zhao, Kunpeng Yi, Nyambayar Batbayar, Tseveenmyadag Natsagdorj, Batmunkh Davaasuren, Xin Wang, Sonia Rozenfeld, Sachiko Moriguchi, Aibin Zhan, Lei Cao, Anthony D. Fox   +12 more
doaj   +1 more source

Absence of population structure across elevational gradients despite large phenotypic variation in mountain chickadees (Poecile gambeli) [PDF]

Royal Society Open Science, 2017
Montane habitats are characterized by predictably rapid heterogeneity along elevational gradients and are useful for investigating the consequences of environmental heterogeneity for local adaptation and population genetic structure.
Carrie L. Branch, Joshua P. Jahner, Dovid Y. Kozlovsky, Thomas L. Parchman, Vladimir V. Pravosudov   +4 more
doaj   +1 more source

The population genetics of structural variation [PDF]

Nature Genetics, 2007
Population genetics is central to our understanding of human variation, and by linking medical and evolutionary themes, it enables us to understand the origins and impacts of our genomic differences. Despite current limitations in our knowledge of the locations, sizes and mutational origins of structural variants, our characterization of their ...
Donald F, Conrad, Matthew E, Hurles
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Significant genetic differentiation between native and introduced farmed Burmese pythons and low risk of genetic introgression from escaped farmed individuals in Hainan Island

Conservation Science and Practice
The Burmese python (Python bivittatus) is one of the most endangered pythons and is commonly traded in the international pet industry. In addition to wild P.
Jiao Qing, Xiaofei Zhai, Shaopeng Yu, Feiyun Tu, Tongliang Wang, Jichao Wang   +5 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source