Results 111 to 120 of about 1,755,519 (297)

Meta-Genetic Programming: Co-evolving the Operators of Variation [PDF]

, 2001
The standard Genetic Programming approach is augmented by co-evolving the genetic operators. To do this the operators are coded as trees of indefinite length.
Edmonds, Bruce
core  

Genetic Characterization of the Arabic-Speaking Population from the Casablanca-Settat Region Using Autosomal STR Markers: Understanding the Interplay of Geography and Language in Moroccan Population History

Forensic Sciences
Background/Objectives: The Casablanca-Settat region of Morocco, located at the interface between Arab and Amazigh cultural zones, has only recently been investigated using autosomal short tandem repeat (STR) markers.
Othmane Essoubaiy, Adnane Hakem, Faiza Chbel, Hakima Yahia, Hicham EL Ossmani, Taoufiq Fechtali, Brahim El Houate   +6 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Biotechnologies in rubber tree (Hevea brasiliensis) : [Draft] [PDF]

, 2007
Rubber tree breeding and the dissemination of planting material for plantations are closely linked to propagation methods. Since the progress made by switching from multiplication by seed to propagation by budding, the development of new techniques, such
Carron, Marc-Philippe, Clément-Demange, André, Lardet, Ludovic, Leclercq, Julie, Montoro, Pascal   +4 more
core  

1. Genetic engineering: The new techniques and their potential

California Agriculture, 1982
Not available – first paragraph follows: In one sense, genetic engineering of plants is really nothing new. Since the beginnings of agriculture, when crop species were first domesticated, people have modified plants to suit their needs.
C Meredith
doaj  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Preimplantational genetic diagnosis: an actual alternative with future implications [PDF]

MedUNAB, 2005
Preimplantational genetic diagnosis (PGT) isa new technique, promoted as an alternative for prenatal diagnosisand eventually for the voluntary termination of pregnancy whenthe couple is willing .
Claudia Juliana Serrano Serrano
doaj  

Correction: Diet of the brown bear in Himalaya: Combining classical and molecular genetic techniques. [PDF]

PLoS One, 2020
Nawaz MA, Valentini A, Khan NK, Miquel C, Taberlet P, Swenson JE.   +5 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source