Results 111 to 120 of about 828,986 (313)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Introducing a Parallel Genetic Algorithm for Global Optimization Problems
AppliedMathThe topic of efficiently finding the global minimum of multidimensional functions is widely applicable to numerous problems in the modern world. Many algorithms have been proposed to address these problems, among which genetic algorithms and their ...
Vasileios Charilogis, Ioannis G. Tsoulos
doaj +1 more source
Selective breeding program for genetic improvement of Macrobrachium rosenbergii in Thailand.
, 2005 Although the giant freshwater prawn (Macrobrachium rosenbergii) has been domesticated in Thailand for over decades, appropriate selective breeding program has yet to be achieved. Good quality seeds for the Machrobrachium aquaculture industry is therefore
Sodsuk, Panom K. +1 more
core
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
BRCA1/2 testing in patients with breast and ovarian cancer [PDF]
Archive of Oncology, 2002 Perović Jelica +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Forensic SciencesBackground/Objectives: The Casablanca-Settat region of Morocco, located at the interface between Arab and Amazigh cultural zones, has only recently been investigated using autosomal short tandem repeat (STR) markers.
Othmane Essoubaiy +6 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Optimisation of multiplier-less FIR filter design techniques
This thesis is concerned with the design of multiplier-less (ML) finite impulse response (FIR) digital filters. The use of multiplier-less digital filters results in simplified filtering structures, better throughput rates and higher speed.
Cemes, Radovan
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source