Results 91 to 100 of about 753,278 (264)

Correction: Diet of the brown bear in Himalaya: Combining classical and molecular genetic techniques. [PDF]

PLoS One, 2020
Nawaz MA, Valentini A, Khan NK, Miquel C, Taberlet P, Swenson JE.   +5 more
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Phloretin-nanospanlastics for targeting the Akt/PI3K signaling pathways in dimethylhydrazine-induced colon cancer in mice

International Journal of Pharmaceutics: X
Objectives: Colorectal cancer is the third most common cancer worldwide, accounting for approximately 10 % of all cancer cases. It is also the second leading cause of cancer-related deaths globally.
Ebtsam A. Abdel-Wahab, Zahraa Haleem Al-Qaim, Ahmed T.H. Faris Al-Karkhi, Aysam M. Fayed, Ahmed M. Eldmrdash, Mohammed Abdalla Hussein, Amal Abdel-Aziz, Azza M. Metwaly, Heba.G. Abdelzaher, M.A. Abdelzaher, Diana A. ALsherif   +10 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

THE SPECIATION IN GENETIC ALGORITHMS FOR PRESERVING POPULATION DIVERSITY AND OPTIMIZATION OF FUNCTIONS WITH SUBOPTIMAL SOLUTIONS

Електроніка та інформаційні технології
Background. Genetic algorithms are used in various tasks and show advantages compared to other optimization methods, which may not always be applicable. However, there are cases when they can’t provide the best possible solution.
V. Pretsel, Roman Shuvar
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Low Rate of Germline Investigation for Variants of Suspected Germline Origin Detected During the Diagnostic Work‐Up of Myeloid Neoplasms

eJHaem
Background Genomic profiling of patients with myeloid neoplasms (MN) may detect variants with high variant allele frequency (VAF), indicating potential germline origin. All current guidelines recommend further investigation of such variants. Objective To
Ahmed Al‐Djaber, Arielle Munters, Jörg Cammenga, Tatjana Pandzic, Rose‐Marie Amini, Claes Ladenvall, Thale Kristin Olsen, Panagiotis Baliakas   +7 more
doaj   +1 more source

Optimization of the fermentation process and antioxidant activity of mixed lactic acid bacteria for honeysuckle beverage

Frontiers in Microbiology
The aim of the research was to obtain a high healthcare honeysuckle beverage with strong antioxidant activity. Honeysuckle (Lonicera japonica Thunb) was used as the raw material in this experiment.
Junjian Ran, Yuhan Tang, Weize Mao, Xia Meng, Lingxia Jiao, Yongchao Li, Ruixiang Zhao, Haoyu Zhou   +7 more
doaj   +1 more source