Results 71 to 80 of about 753,278 (264)
Cytogenetic and Biochemical Genetic Techniques for Personalized Drug Therapy in Europe. [PDF]
Diagnostics (Basel), 2021 Huebner T, Scholl C, Steffens M.
europepmc +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Synthesized boron compounds: Neurotoxic and oxidative effects in an model of Alzheimer's disease
Science ProgressObjective Alzheimer's disease (AD) is characterized by amyloid-beta (Aβ1–42) aggregation, oxidative stress, and neuronal loss, necessitating novel therapeutic agents to mitigate these pathological hallmarks.
Sibel Bayıl +2 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Aspirin resistance: clinical and molecular genetic evaluation techniques
Анналы клинической и экспериментальной неврологии, 2017 The article discusses the issues related to the personalization of preventive measures for ischemic stroke, in particular those associated with resistance to one of the most common antiplatelet drugs, aspirin.
M. M. Tanashyan +2 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Comparison of multiple watermarking techniques using genetic algorithms
Journal of Electrical Systems and Information Technology, 2016 Multiple watermarking is used to share the copyright of multiple users, increase robustness and high security. The proposed method is comparison of multiple-watermarking techniques based on Discrete Wavelet Transform and Singular Value Decomposition ...
N. Mohananthini, G. Yamuna
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Introducing a Parallel Genetic Algorithm for Global Optimization Problems
AppliedMathThe topic of efficiently finding the global minimum of multidimensional functions is widely applicable to numerous problems in the modern world. Many algorithms have been proposed to address these problems, among which genetic algorithms and their ...
Vasileios Charilogis, Ioannis G. Tsoulos
doaj +1 more source