Results 71 to 80 of about 1,755,519 (297)

Prenatal genetic diagnosis of monogenic diseases

Advances in Laboratory Medicine, 2023
Prenatal genetic diagnosis of monogenic diseases is a process involving the use of a variety of molecular techniques for the molecular characterization of a potential monogenic disease in the fetus during pregnancy.
Prior-de Castro Carmen, Gómez-González Clara, Rodríguez-López Raquel, Macher Hada C.,   +4 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Assessing the Impact of Nitrogen Fertilization, Variety Selection, Year and Their Interaction on Wheat Yield and Yield Components

Nitrogen
This five-year study (2016–2021) in Morocco’s Mediterranean climate investigated the effect of nitrogen fertilization and genotypic selection on wheat yield and associated components. Utilizing a split-plot design, the study assessed five wheat genotypes—
Oussama Hnizil, Aziz Baidani, Ilham Khlila, Nasserelhaq Nsarellah, Ali Amamou   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

New Molecular Genetic Techniques for the Inference of Evolutionary Relationships

Acta Biologica Slovenica, 1991
Molecular genetic techniques have advanced greatly in the last few years, and provided powerful tools for phylogenetic research. The two most important methods for characterising nucleic acids are restriction-enzyme fragment analysis, and nucleotide ...
Adam Marchant
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Dissecting Genotype by Environment Interactions in Moroccan Wheat: An Advanced Biplot and Heatmap Analysis Unveiling Agronomic, Quality Traits, and Genotypic Stability for Tailored Breeding Strategies

Plants
This five-year study (2016–2021) across diverse Moroccan agro-climatic zones investigated genotype by environment (G × E) interactions in wheat, focusing on variations in agronomic traits and quality attributes such as protein and gluten content ...
Oussama Hnizil, Aziz Baidani, Ilham Khlila, Mouna Taghouti, Nasserelhaq Nsarellah, Ali Amamou   +5 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Highly efficient Localisation utilising Weightless neural systems [PDF]

, 2012
Efficient localisation is a highly desirable property for an autonomous navigation system. Weightless neural networks offer a real-time approach to robotics applications by reducing hardware and software requirements for pattern recognition techniques ...
Batchelor, John, Gillham, Michael, Howells, Gareth, Kelly, Stephen, McElroy, Ben, Pepper, Matthew, Spurgeon, Sarah   +6 more
core