Results 61 to 70 of about 828,986 (313)

Genetic Algorithms and Genetic Programming for Control

, 1997
The use of genetic algorithms and genetic programming in control engineering has started to expand in the last few years. This is mainly for two reasons: the physical cost of implementing a known control algorithm and the difficulty to find such an ...
Dracopoulos, D.
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Anthropogenetic study of the Arabic - speaking population of Chaouia Ouardigha (Morocco) based on autosomal STRs

Egyptian Journal of Forensic Sciences
Background The Chaouia - Ouradigha is a historical and ethno-geographic region of Morocco. Despite its historical relevance, this region has not received sufficient attention in terms of population genetic exploration.
Othmane Essoubaiy, Bouchaïb Gazzaz, Hakima Yahia, Hicham EL Ossmani, Jalal Talbi, Brahim El Houate, Taoufiq Fechtali   +6 more
doaj   +1 more source

3-[2-(2-Amino-1H-benzo[d]imidazol-1-yl)ethyl]-1,3-oxazolidin-2-one

IUCrData, 2016
In the title compound, C12H14N4O2, the benzimidazole ring is almost planar (r.m.s. deviation = 0.03 Å), with the fused ring system slightly folded at the shared atoms, with a dihedral angle of 3.4 (1)°.
Abdellatif Bouayyadi, Ahmed Moussaif, Abdelhalim Mesfioui, Mohammed Mzibri, Mohamed Saadi, Lahcen El Ammari   +5 more
doaj   +1 more source

Prenatal genetic diagnosis of monogenic diseases

Advances in Laboratory Medicine, 2023
Prenatal genetic diagnosis of monogenic diseases is a process involving the use of a variety of molecular techniques for the molecular characterization of a potential monogenic disease in the fetus during pregnancy.
Prior-de Castro Carmen, Gómez-González Clara, Rodríguez-López Raquel, Macher Hada C.,   +4 more
doaj   +1 more source

Learning to Solve Planning Problems Efficiently by Means of Genetic Programming [PDF]

, 2001
Declarative problem solving, such as planning, poses interestig challenges for Genetic Programming (GP). In the recent past there have been several attempts to apply GP to planning which basically t two approaches: (a) using GP to search in plan ...
Borrajo, Daniel, Pedro Isasi, Aler, Ricardo, Daniel Borrajo, Borrajo Millán, Daniel, Ricardo Aler, Aler Mur, Ricardo, Isasi, Pedro, Isasi Viñuela, Pedro   +8 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Assessing the Impact of Nitrogen Fertilization, Variety Selection, Year and Their Interaction on Wheat Yield and Yield Components

Nitrogen
This five-year study (2016–2021) in Morocco’s Mediterranean climate investigated the effect of nitrogen fertilization and genotypic selection on wheat yield and associated components. Utilizing a split-plot design, the study assessed five wheat genotypes—
Oussama Hnizil, Aziz Baidani, Ilham Khlila, Nasserelhaq Nsarellah, Ali Amamou   +4 more
doaj   +1 more source