Results 81 to 90 of about 828,986 (313)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Effect of ginger, chamomile, and green tea extracts on prostate cancer cells

Journal of Genetic Engineering and Biotechnology
Prostate cancer (PCa) is a prevalent form of malignancy in males and is a significant contributor to cancer-related mortality worldwide. Because of this, studying the molecular processes of PCa cell growth and death is crucial. Hence, it is imperative to
Aysam M. Fayed, M.A. Abdelzaher, Neamah Hassoni Mahdi, Dina M.R. AlKhafaf, Mohamed AbdElRahman, Ahmed Khalid Aldhalmi, Zahraa Haleem Al-Qaim, Rania Abd Elmohsen Abo El nour, Heba G. Abdelzaher, Alaa Muqbil Alsirhani, Salwa El. Saied Morsi   +10 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Advancements and Challenges in Preimplantation Genetic Testing for Aneuploidies: In the Pathway to Non-Invasive Techniques

The evolution of preimplantation genetic testing for aneuploidy (PGT-A) techniques has been crucial in assisted reproductive technologies (ARTs), improving embryo selection and increasing success rates in in vitro fertilization (IVF) treatments ...
Ana del Arco de la Paz, Marcos Meseguer, Aikaterini Selntigia, Carla Giménez-Rodríguez, Daniela Galliano   +4 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Identification of EMS-induced sesame (Sesamum indicum L.) mutants with improved low-temperature tolerance during germination and early seedling growth

Frontiers in Plant Science
Sesame (Sesamum indicum L.) is a valuable oilseed crop in Morocco, but its cultivation is strictly constrained by sensitivity to low temperatures during early-season sowing.
Nouhayla Tahri, Nouhayla Tahri, Boutaina Louafi, Mohamed Kouighat, Karima Mikou, Abdelghani Nabloussi   +5 more
doaj   +1 more source

Molecular Genetic Techniques for the Proteoglycan Functions in Drosophila. [PDF]

Methods Mol Biol, 2022
Bowden N, Takemura M, Nakato H.
europepmc   +1 more source

OPTIMIZING PROJECT TIME-COST-QUALITY BY USING GENETIC ALGORITHMS [PDF]

Project management causes the problem of efficient resource assignment, activity, time constraints and relationships between activities. Traditional scheduling methods like CPM and PERT are incomplete tools to use in practice because they do not consider
Ileana Ruxandra BADEA, Constanta-Nicoleta BODEA   +1 more
core  

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source