Results 91 to 100 of about 1,972,073 (332)
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
NQO1 polymorphism and susceptibility to ischemic stroke in a Chinese population
BMC Medical GenomicsBackground Ischemic stroke (IS) is a major cause of death and disability worldwide. Genetic factors are important risk factors for the development of IS.
Min Wang +6 more
doaj +1 more source
Heliyon, 2023 Objectives: To evaluate a two-test strategy for HIV screening in the low-prevalence population and to assess the feasibility of utilizing the optimal signal-to-cutoff (S/CO) threshold on the chemiluminescence immunoassay(CMIA) and an additional rapid ...
Yu Huang +8 more
doaj
Conditional inference in cis-Mendelian randomization using weak genetic factors [PDF]
arXiv, 2020 Mendelian randomization is a widely-used method to estimate the unconfounded effect of an exposure on an outcome by using genetic variants as instrumental variables. Mendelian randomization analyses which use variants from a single genetic region (cis-MR) have gained popularity for being an economical way to provide supporting evidence for drug target ...
arxiv
Attitudes Toward Breast Cancer Genetic Testing in Five Special Population Groups
, 2015 Purpose: This study examined interest in and attitudes toward genetic testing in 5 different population groups. Methods: The survey included African American, Asian American, Latina, Native American, and Appalachian women with varying familial histories ...
Burhansstipanov, Linda +9 more
core
Developing genetic learning module baased on blue eyes phenomenon in Buton Island, Southeast Sulawesi [PDF]
, 2019 The existence of learning resources based on local phenomena is presumed to be able to optimize genetic learning processes. The purposes of this study were (1) to produce module based on the blue eyes phenomenon occurred in Buton Island for genetic ...
Ikhsan Taharu, Fahmil +2 more
core +2 more sources
Brucella NyxA and NyxB dimerization enhances effector function during infection
FEBS Letters, EarlyView.Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre +4 more
wiley +1 more source
Automated unique input output sequence generation for conformance testing of FSMs [PDF]
, 2005 This paper describes a method for automatically generating unique input output (UIO) sequences for FSM conformance testing. UIOs are used in conformance testing to verify the end state of a transition sequence. UIO sequence generation is represented as a
Derderian, K +3 more
core +4 more sources
FEBS Letters, EarlyView.UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg +2 more
wiley +1 more source
Point-of-care genetic counselling : should family physicians counsel patients on genetic testing and screening? [PDF]
, 2015 Family medicine has come of age, with family doctors/general practitioners taking on greater roles and responsibilities and health care systems recognizing the important role of primary care. It is in this scenario that the question of pre- and post-
Mallia, Pierre
core