Results 91 to 100 of about 1,824,368 (348)
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
To Warn or Not to Warn? Genetic Information, Families, and Physician Liability
McGill Journal of Medicine, 2020 Genetic testing raises a number of legal issues. Physicians providing genetic testing may be faced with questions related to privacy, confidentiality, and the duty to warn.
Jennifer L Gold
doaj +1 more source
NQO1 polymorphism and susceptibility to ischemic stroke in a Chinese population
BMC Medical GenomicsBackground Ischemic stroke (IS) is a major cause of death and disability worldwide. Genetic factors are important risk factors for the development of IS.
Min Wang +6 more
doaj +1 more source
Heliyon, 2023 Objectives: To evaluate a two-test strategy for HIV screening in the low-prevalence population and to assess the feasibility of utilizing the optimal signal-to-cutoff (S/CO) threshold on the chemiluminescence immunoassay(CMIA) and an additional rapid ...
Yu Huang +8 more
doaj
Testing Quantum Dynamics in Genetic Information Processing [PDF]
, 2001 Does quantum dynamics play a role in DNA replication? What type of tests would reveal that? Some statistical checks that distinguish classical and quantum dynamics in DNA replication are proposed.Comment: 4 pages, latex.
Patel, Apoorva
core +1 more source
Clinical and molecular characterization of a cardiac ryanodine receptor founder mutation causing catecholaminergic polymorphic ventricular tachycardia [PDF]
, 2015 Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a difficult-to-diagnose cause of sudden cardiac death (SCD). We identified a family of 1400 individuals with multiple cases of CPVT, including 36 SCDs during youth.
Allegue, Catarina +12 more
core +2 more sources
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
Developing genetic learning module baased on blue eyes phenomenon in Buton Island, Southeast Sulawesi [PDF]
, 2019 The existence of learning resources based on local phenomena is presumed to be able to optimize genetic learning processes. The purposes of this study were (1) to produce module based on the blue eyes phenomenon occurred in Buton Island for genetic ...
Ikhsan Taharu, Fahmil +2 more
core +2 more sources
FEBS Letters, EarlyView.In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi +5 more
wiley +1 more source
Point-of-care genetic counselling : should family physicians counsel patients on genetic testing and screening? [PDF]
, 2015 Family medicine has come of age, with family doctors/general practitioners taking on greater roles and responsibilities and health care systems recognizing the important role of primary care. It is in this scenario that the question of pre- and post-
Mallia, Pierre
core