Results 81 to 90 of about 5,304,709 (301)

NQO1 polymorphism and susceptibility to ischemic stroke in a Chinese population

BMC Medical Genomics
Background Ischemic stroke (IS) is a major cause of death and disability worldwide. Genetic factors are important risk factors for the development of IS.
Min Wang, Ying Shen, Yuan Gao, Huaqiu Chen, Fuhui Duan, Siying Li, Guangming Wang   +6 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Current practice in diagnostic genetic testing of the epilepsies [PDF]

, 2022
Epilepsy genetics is a rapidly developing field, in which novel disease-associated genes, novel mechanisms associated with epilepsy, and precision medicine approaches are continuously being identified.
Berkovic, Samuel F, Weber, Yvonne, Hildebrand, Michael S., Sisodiya, Sanjay M., Helbig, Ingo, Sisodiya, Sanjay M, Platzer, Konrad, Wilmshurst, Jo M., Wilmshurst, Jo M, Berkovic, Samuel F., Hildebrand, Michael S, Lowenstein, Daniel, Weckhuysen, Sarah, Poduri, Annapurna, Lemke, Johannes R., Krey, Ilona, Esterhuizen, Alina, Lerche, Holger, Møller, Rikke S, Lemke, Johannes R, Moller, Rikke S., Sadleir, Lynette   +21 more
core  

Machine learning models based on routine blood and biochemical test data for diagnosis of neurological diseases

Scientific Reports
Globally, nervous system diseases are the leading cause of disability-adjusted life-years and the second leading cause of mortality in the world. Traditional diagnostic methods for nervous system diseases are expensive.
Wanshan Ning, Zhicheng Wang, Ying Gu, Lindan Huang, Shuai Liu, Qun Chen, Yunyun Yang, Guolin Hong   +7 more
doaj   +1 more source

Spatial and Temporal Patterns of Trace Element Deposition in Urban Thessaloniki: A Syntrichia Moss Biomonitoring Study

Atmosphere
Urban air pollution, especially from heavy metal (HM) contamination, poses significant risks to human health and environmental sustainability. This study investigates the spatial and temporal distribution of HM contamination in Thessaloniki, Greece ...
Themistoklis Sfetsas, Sopio Ghoghoberidze, Panagiotis Karnoutsos, Vassilis Tziakas, Marios Karagiovanidis, Dimitrios Katsantonis   +5 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Genetic Testing When There is a Mix of Compulsory and Voluntary Health Insurance [PDF]

Genetic insurance can deal with the negative effects of genetic testing on insurance coverage and income distribution when the insurer has access to information about test status. Hence, efficient testing is promoted.
Tor Iversen, Michael Hoel
core  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Corrigendum: A novel BRCA1 splicing variant detected in an early onset triple-negative breast cancer patient additionally carrying a pathogenic variant in ATM: a case report

Frontiers in Oncology, 2023
Mara Colombo, Patrizia Mondini, Elisa Minenza, Claudia Foglia, Annamaria Mosconi, Carmen Molica, Lorenza Pistola, Vienna Ludovini, Paolo Radice   +8 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source