Results 81 to 90 of about 1,937,571 (305)

Serum metabolomics-based diagnostic biomarkers for colorectal cancer: insights and multi-omics validation

Frontiers in Endocrinology
BackgroundColorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide, primarily due to delayed diagnosis. There is an urgent need for sensitive, noninvasive biomarkers that can facilitate early detection and improve ...
Taorui Wang, Yuanxu Gao, Yuanxu Gao, Zhihai Liu, Zhihai Liu, Peng Du, Peng Du, Shengjun Tang, Shengjun Tang, Zijun Lai, Zijun Lai, Gen Li   +11 more
doaj   +1 more source

Familial hypercholesterolemia: a systematic review of guidelines on genetic testing and patient management [PDF]

, 2017
BACKGROUND: Familial hypercholesterolemia (FH) is an autosomal-dominant hereditary disorder of lipid metabolism that causes lifelong exposure to increased LDL levels resulting in premature coronary heart disease and, if untreated, death.
Baccolini, Valentina, D'Andrea, Elvira, De Vito, Corrado, Massimi, Azzurra, Migliara, Giuseppe, Rosso, Annalisa, Villari, Paolo   +6 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Spatial and Temporal Patterns of Trace Element Deposition in Urban Thessaloniki: A Syntrichia Moss Biomonitoring Study

Atmosphere
Urban air pollution, especially from heavy metal (HM) contamination, poses significant risks to human health and environmental sustainability. This study investigates the spatial and temporal distribution of HM contamination in Thessaloniki, Greece ...
Themistoklis Sfetsas, Sopio Ghoghoberidze, Panagiotis Karnoutsos, Vassilis Tziakas, Marios Karagiovanidis, Dimitrios Katsantonis   +5 more
doaj   +1 more source

Genetic aspects of calving, growth, and carcass traits in beef cattle [PDF]

, 2003
The aim of this thesis was to learn more about the genetic background of calving, growth and carcass traits of beef cattle breeds in Sweden, and to assess the possibility of including calving traits and commercial carcass traits in the genetic evaluation.
Eriksson, Susanne
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

NQO1 polymorphism and susceptibility to ischemic stroke in a Chinese population

BMC Medical Genomics
Background Ischemic stroke (IS) is a major cause of death and disability worldwide. Genetic factors are important risk factors for the development of IS.
Min Wang, Ying Shen, Yuan Gao, Huaqiu Chen, Fuhui Duan, Siying Li, Guangming Wang   +6 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Machine learning models based on routine blood and biochemical test data for diagnosis of neurological diseases

Scientific Reports
Globally, nervous system diseases are the leading cause of disability-adjusted life-years and the second leading cause of mortality in the world. Traditional diagnostic methods for nervous system diseases are expensive.
Wanshan Ning, Zhicheng Wang, Ying Gu, Lindan Huang, Shuai Liu, Qun Chen, Yunyun Yang, Guolin Hong   +7 more
doaj   +1 more source

How Can We Move Clinical Genomics Beyond the Hype? [PDF]

, 2011
Examines the debate over increased use of genetic testing, due in part to lax regulation, and its consequences: wasteful spending, patient harm, and health system challenges.
Michael L. Millenson
core