Results 61 to 70 of about 951,804 (263)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Serum metabolomics-based diagnostic biomarkers for colorectal cancer: insights and multi-omics validation

Frontiers in Endocrinology
BackgroundColorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide, primarily due to delayed diagnosis. There is an urgent need for sensitive, noninvasive biomarkers that can facilitate early detection and improve ...
Taorui Wang, Yuanxu Gao, Yuanxu Gao, Zhihai Liu, Zhihai Liu, Peng Du, Peng Du, Shengjun Tang, Shengjun Tang, Zijun Lai, Zijun Lai, Gen Li   +11 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

NQO1 polymorphism and susceptibility to ischemic stroke in a Chinese population

BMC Medical Genomics
Background Ischemic stroke (IS) is a major cause of death and disability worldwide. Genetic factors are important risk factors for the development of IS.
Min Wang, Ying Shen, Yuan Gao, Huaqiu Chen, Fuhui Duan, Siying Li, Guangming Wang   +6 more
doaj   +1 more source

Spatial and Temporal Patterns of Trace Element Deposition in Urban Thessaloniki: A Syntrichia Moss Biomonitoring Study

Atmosphere
Urban air pollution, especially from heavy metal (HM) contamination, poses significant risks to human health and environmental sustainability. This study investigates the spatial and temporal distribution of HM contamination in Thessaloniki, Greece ...
Themistoklis Sfetsas, Sopio Ghoghoberidze, Panagiotis Karnoutsos, Vassilis Tziakas, Marios Karagiovanidis, Dimitrios Katsantonis   +5 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Machine learning models based on routine blood and biochemical test data for diagnosis of neurological diseases

Scientific Reports
Globally, nervous system diseases are the leading cause of disability-adjusted life-years and the second leading cause of mortality in the world. Traditional diagnostic methods for nervous system diseases are expensive.
Wanshan Ning, Zhicheng Wang, Ying Gu, Lindan Huang, Shuai Liu, Qun Chen, Yunyun Yang, Guolin Hong   +7 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source