Results 71 to 80 of about 5,304,709 (301)

Men's decision-making about predictive BRCA1/2 testing: the role of family [PDF]

, 2005
Men who have a family history of breast and/or ovarian cancer may be offered a predictive genetic test to determine whether or not they carry the family specific BRCA1/2 mutation.
Moynihan, C., R. Eeles, A. Lucassen, Eeles, R., Hallowell, N., A. Ardern‐Jones, C. Foster, Ardern-Jones, A., M. Watson, Lucassen, A., Foster, C., Watson, M., C. Moynihan, N. Hallowell   +13 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Pathology and Genetic Testing

, 1997
Workshop of Heritable Cancer and Genetic Testing: Workshop No.
Thor, Ann, Luce, Michael, Page, David L., Willis, Dawn, Parsons, Ramon, Markowitz, Sanford, Holt, Jeffrey T., Decker, Ruth A., Mulcahy, Gabriel M., Mauer, Alvin M., Goggins, Michael, Narod, Steven A.   +11 more
core  

Serum metabolomics-based diagnostic biomarkers for colorectal cancer: insights and multi-omics validation

Frontiers in Endocrinology
BackgroundColorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide, primarily due to delayed diagnosis. There is an urgent need for sensitive, noninvasive biomarkers that can facilitate early detection and improve ...
Taorui Wang, Yuanxu Gao, Yuanxu Gao, Zhihai Liu, Zhihai Liu, Peng Du, Peng Du, Shengjun Tang, Shengjun Tang, Zijun Lai, Zijun Lai, Gen Li   +11 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Nightline: Genetic Testing for Alzheimer's (2000)

, 2000
"Genetic Testing for Alzheimer's Nightline takes a closer look at genetic testing for Alzheimer's and the ethical dilemma over marketing such a test when no cure is available" (from ABC web ...

core  

Unexpected High Need for Genetic Testing in Rheumatology: A Cross-Sectional Cohort Study

, 2023
Background: Genetic testing may provide information for diagnostic, prognostic and pharmacogenetic purposes. The PREPARE study recently showed that the number of clinically relevant adverse drug reactions could be reduced via genotype-guided treatment ...
Lukas Kampik, Michael Schirmer
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

FRAMEWORKS OF CHOICE: PREDICTIVE AND GENETIC TESTING IN ASIA

, 2010
Acronyms -- Acknowledgements -- 1. Frameworks of choice: the ramification of predictive and genetic testing in Asia / Margaret Sleeboom-Faulkner -- 2.
Sleeboom-Faulkner, Margaret, ed.
core  

WHO HAS TO UNDERGO CANCER GENETIC TESTING? A PERSPECTIVE.

, 2017
Genetic testing is a medical tool employed to screen changes in genes linked to cancer and other genetic diseases. Genetic tests are available for breast, ovarian, colon, thyroid, and some other cancers and they represent the main tool for early ...
Carmen Rinaldi
core   +1 more source