Results 41 to 50 of about 959,012 (263)

The Bottleneck in Genetic Testing [PDF]

Circulation Research, 2015
Progress in science is a continuum but not uniform. Occasional sparks, typically ignited by the so-called disruptive discoveries, decorate the continuum. Relevant to this editorial on advances in the genetic testing technologies, is the disruptive technology of capillary sequencing, also known as Sanger sequencing.1 It enabled the initial sequencing of
openaire   +2 more sources

Genetic Testing for Pheochromocytoma [PDF]

Current Hypertension Reports, 2010
Pheochromocytomas (PHEOs) and paragangliomas (PGLs) are rare, catecholamine-producing tumors that are usually sporadic. However, about 30% of these tumors have been identified as being of inherited origin. To date, nine genes have been confirmed as participating in PHEO or PGL tumorigenesis.
David, Karasek, Zdenek, Frysak, Karel, Pacak   +2 more
openaire   +2 more sources

Early Impact of Childhood Opportunity on Neurocognitive Outcomes in Sickle Cell Disease

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurocognitive impairment is a well‐recognized complication of sickle cell disease (SCD) that begins early in childhood and persists across development. While cerebrovascular injury contributes substantially to risk, neurocognitive deficits are also observed in children without overt or silent cerebral infarctions, suggesting ...
Julia E. LaMotte, Hannah Koch, Olivia A. Coughlin, Jillian R. Bouck, Allie Carter, Seethal A. Jacob   +5 more
wiley   +1 more source

DIEANet: an attention model for histopathological image grading of lung adenocarcinoma based on dimensional information embedding

Scientific Reports
Efficient and rapid auxiliary diagnosis of different grades of lung adenocarcinoma is conducive to helping doctors accelerate individualized diagnosis and treatment processes, thus improving patient prognosis. Currently, there is often a problem of large
Zexin Wang, Jing Gao, Min Li, Enguang Zuo, Chen Chen, Cheng Chen, Fei Liang, Xiaoyi Lv, Yuhua Ma   +8 more
doaj   +1 more source

Gene expression-based dissection of inter-histotypes, intra-histotype and intra-tumor heterogeneity in pediatric tumors

Scientific Reports, 2022
Intra-tumor heterogeneity (ITH) fosters tumor evolution, resistance to therapy, and relapse. Recently, many evidence have been accumulated on the occurrence of genetic ITH in pediatric cancers.
Sara Ciceri, Andrea Carenzo, Maria Federica Iannó, Alessia Bertolotti, Carlo Morosi, Roberto Luksch, Filippo Spreafico, Paola Collini, Paolo Radice, Maura Massimino, Loris De Cecco, Daniela Perotti   +11 more
doaj   +1 more source

Incidence and Severity of Carboplatin‐Associated Hearing Loss in Children With Cancer Assessed by the SIOP Boston 2012 Ototoxicity Criteria

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Platinum‐based chemotherapy is known to cause severe and debilitating hearing loss, but unlike cisplatin, the true incidence of carboplatin‐induced hearing loss remains unclear. We evaluated functional hearing outcomes in children receiving carboplatin to determine the incidence and severity of ototoxicity. Procedure We identified a
Aniket Chawla, Sean Carter, Andrew Wood, Sandra Staffieri, Andrew Dodgshun, David D. Eisenstat, Michael Sullivan   +6 more
wiley   +1 more source

Rapid detection of Pseudomonas aeruginosa by glycerol one-pot RAA/CRISPR-Cas12a method

Frontiers in Chemistry
Pseudomonas aeruginosa (PA), an opportunistic pathogen commonly responsible for hospital-acquired infections, poses significant threats to human health.
Lijian Wei, Lijian Wei, Lijian Wei, Lijian Wei, Lijian Wei, Lijian Wei, Shihua Luo, Shihua Luo, Shihua Luo, Shihua Luo, Shihua Luo, Weijie Zhou, Baoyan Ren, Baoyan Ren, Miao Li, Lina Liang, Lina Liang, Lina Liang, Lina Liang, Lina Liang, Xuebin Li, Xuebin Li, Xuebin Li, Xuebin Li, Guijiang Wei, Guijiang Wei, Guijiang Wei, Guijiang Wei, Guijiang Wei, Guijiang Wei   +29 more
doaj   +1 more source

Re‐Irradiation in Pediatric Diffuse Midline Glioma: A Multi‐Institutional Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with recurrent diffuse midline gliomas (DMGs) have limited therapeutic options at recurrence. Re‐irradiation (RT2) may be used at progression, but with uncertainty about the benefit. Methods We conducted a multi‐institutional retrospective study of children aged < 18 with DMG treated at three centers (Toronto, Canada ...
Ajay Thomas Alex, Sean P. Hassan, Helen Benghiat, Liam Herbert, Jennifer Adamski, Shivani Bailey, Claire Esler, Louise Brookes, Molly Bamber, Grace Koudou, Karen Waite, Julie Bennett, Anirban Das, Derek S. Tsang   +13 more
wiley   +1 more source

Klebsiella pneumoniae detection by a light-controlled one-pot RPA-CRISPR/Cas12a method

Frontiers in Cellular and Infection Microbiology
BackgroundKlebsiella pneumoniae (KP) is a significant pathogenic bacterium responsible for severe infections in hospitals. However, existing traditional detection techniques, such as culture and PCR, are relatively inefficient. Therefore, this study aims
Lele Pan, Lele Pan, Lele Pan, Lele Pan, Lele Pan, Lijian Wei, Lijian Wei, Lijian Wei, Lijian Wei, Lijian Wei, Lijian Wei, Shihua Luo, Shihua Luo, Shihua Luo, Shihua Luo, Shihua Luo, Baoyan Ren, Baoyan Ren, Miao Li, Lina Liang, Lina Liang, Lina Liang, Lina Liang, Lina Liang, Xuebin Li, Xuebin Li, Xuebin Li, Xuebin Li, Guijiang Wei, Guijiang Wei, Guijiang Wei, Guijiang Wei, Guijiang Wei, Guijiang Wei   +33 more
doaj   +1 more source

Epidemiology and Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae and Subsequent MALDI-TOF MS as a Tool to Cluster KPC-2-Producing Klebsiella Pneumoniae, a Retrospective Study

Frontiers in Cellular and Infection Microbiology, 2020
Background: Carbapenem-resistant Klebsiella pneumoniae (CRKP) appeared recently and now presents a particularly critical problem to hospitalized patients worldwide.
Lili Fang, Lili Fang, Lili Fang, Heping Xu, Heping Xu, Heping Xu, Xiaoying Ren, Xiaoying Ren, Xiaoying Ren, Xun Li, Xun Li, Xun Li, Xiaobo Ma, Xiaobo Ma, Xiaobo Ma, Haijian Zhou, Haijian Zhou, Guolin Hong, Guolin Hong, Guolin Hong, Xianming Liang, Xianming Liang   +21 more
doaj   +1 more source