Results 111 to 120 of about 1,948,626 (333)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Continuous salt stress-induced long non-coding RNAs and DNA methylation patterns in soybean roots
BMC Genomics, 2019 Background Environmental stimuli can activate a series of physiological and biochemical responses in plants accompanied by extensive transcriptional reprogramming.
Rui Chen +7 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Genetic testing for achromatopsia
The EuroBiotech Journal, 2017 We studied the scientific literature and disease guidelines in order to summarize the clinical utility of genetic testing for achromatopsia. The disease has autosomal recessive inheritance, a prevalence of 1/30000-1/50000, and is caused by mutations in ...
Abeshi Andi +5 more
doaj +1 more source
MOLECULAR IDENTIFICATION OF ROOT-KNOT NEMATODES MELOIDOGYNE SPP. ISOLATED FROM CUCUMBER FARMS IN DIFFERENT IRAQI REGIONS [PDF]
مجلة الأنبار للعلوم الزراعيةMeloidogyne spp. is one of the most common crop diseases globally. Due to the similarity in morphological features between various Meloidogyne spp., molecular techniques were used to identify their species.
M. R. Abbas +2 more
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Counting Sheep: Potential Applications of DNA Analysis to the Study of Medieval Parchment Production [PDF]
, 2011 This chapter follows up on several preliminary tests that have shown that DNA survives in medieval parchment manuscript leaves and may be extracted and analyzed, and offers suggestions for defining and implementing future genetic studies of parchment.
Stinson, Timothy
core
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source