Results 111 to 120 of about 1,824,368 (348)

Genetic Monitoring in the Workplace: A Tool Not a Solution [PDF]

, 1999
The authors differentiate between genetic monitoring and screening, and discuss the potential risks and benefits of predictive testing ...
Jablonski, Richard, Musham, Catherine, Trettin, Lillian   +2 more
core   +2 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Corrigendum: A novel BRCA1 splicing variant detected in an early onset triple-negative breast cancer patient additionally carrying a pathogenic variant in ATM: a case report

Frontiers in Oncology, 2023
Mara Colombo, Patrizia Mondini, Elisa Minenza, Claudia Foglia, Annamaria Mosconi, Carmen Molica, Lorenza Pistola, Vienna Ludovini, Paolo Radice   +8 more
doaj   +1 more source

Genetic testing: ethical aspects

Open Medicine, 2018
The aim of this article is to provide an analysis of the main issues related to the application of predictive medicine by analysing the most significant ethical implications.
Bin Paola, Conti Adelaide, Capasso Emanuele, Fedeli Piergiorgio, Policino Fabio, Casella Claudia, Delbon Paola, Graziano Vincenzo   +7 more
doaj   +1 more source

GENETIC SEX: CHROMATIN TEST VERSUS GONADAL HISTOLOGY [PDF]

, 1956
R. G. Bunge, James T. Bradbury
openalex   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

DATA FOR TESTING FOR GENETIC LINKAGE ON 500 PAIRS OF SIBS [PDF]

, 1941
William C. Boyd, Lyle G. Boyd
openalex   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

Genetic testing in neurology

Medicine, 2016
Genetic testing is now an integral part of most areas of medicine, including neurological disorders. This article provides clinicians with guidance on the issues and pathways for genetic testing, including ethical dilemmas that can arise in the care of families with a confirmed or suspected genetic condition. As genetics moves more into the mainstream,
Victoria Harrison, Victoria Harrison, Andrea H. Németh, Andrea H. Németh, Henrietta Lefroy, Henrietta Lefroy   +5 more
openaire   +2 more sources

Impact of the public/private mix of health insurance on genetic testing [PDF]

Privacy of information is a central concern in the debate about genetic testing. Two types of social inefficiencies may occur when information about prevention and test status is private; genetic testing may not be done when it is socially efficient and ...
Hoel, Michael, Iversen, Tor
core