Results 11 to 20 of about 5,304,709 (301)

Genetic Testing [PDF]

New England Journal of Medicine, 2003
Remarkable strides were made in the twentieth century in understanding the basis of heredity and in deciphering how the genes, the units of heredity, function.
Spanier, B. W. Marcel, Bruno, Marco J.
core   +9 more sources

Evidence‐based consensus guidelines for ALS genetic testing and counseling

Annals of Clinical and Translational Neurology, 2023
Objective Advances in amyotrophic lateral sclerosis (ALS) gene discovery, ongoing gene therapy trials, and patient demand have driven increased use of ALS genetic testing. Despite this progress, the offer of genetic testing to persons with ALS is not yet
Jennifer Roggenbuck, Breda H. F. Eubank, Joshua Wright, Matthew B. Harms, Stephen J. Kolb, the ALS Genetic Testing and Counseling Guidelines Expert Panel   +5 more
doaj   +2 more sources

Let the consumer decide? The regulation of commercial genetic testing. [PDF]

, 2001
Objectives—The development of predictive genetic tests provides a new area where consumers can gain knowledge of their health status and commercial opportunities.
Levitt, M. I.
core   +5 more sources

Attitude toward genetic testing for cancer risk in Istanbul

, 2004
To identify attitudes toward genetic testing, and the effects of this information on decisions regarding issues such as pregnancy, abortion, and prophylactic surgery, several subsets of the Turkish Population were surveyed in hospital settings ...
Turhal, NS, BASARAN, Gülcan, BAŞARAN, Gül, TOPAL, A, ALİUSTAOĞLU, MEHMET, ALIUSTAOGLU, M, Yumuk, PF, EKENEL, Meltem, GUMUS, Müjde Dila, Gumus, M   +9 more
core   +3 more sources

Genetic Testing and Genetic Screening [PDF]

Kennedy Institute of Ethics Journal, 1993
In recent years there has been an enormous expansion in the knowledge that may be gleaned from the testing of an individual's genetic material to predict present or future disability or disease either for oneself or one's offspring. The Human Genome Project, which is currently mapping the entire human gene system, is identifying progressively more ...
openaire   +2 more sources

Testing the Children: Do Non-Genetic Health-Care Providers Differ in Their Decision to Advise Genetic Presymptomatic Testing on Minors? A Cross-Sectional Study in Five Countries in the European Union [PDF]

, 2009
BACKGROUND: Within Europe many guidelines exist regarding the genetic testing of minors. Predictive and presymptomatic genetic testing of minors is recommended for disorders for which medical intervention/preventive measures exist, and for which early ...
Kate, L.P. ten, Schmidtke, Joerg, Harris, H.J., Baars, Marieke J.H., Julian-Reynier, Claire, Cornel, Martina C., Kristoffersson, U., Anionwu, E.N., Harris, Rodney, Cornel, M.C., ten Kate, L.P., Anionwu, Elizabeth N., Baars, M.J.H., Benjamin, Caroline, Schmidtke, Jörg, Harris, H., Schmidtke, J., Challen, K., Harris, R, Julian-Reynier, C., Harris, Hillary, Plass, A.M.C., Harris, R., Plass, Anne Marie C., Baars, Marieke J. H., Nippert, I., Challen, Kirsty, Nippert, Irmgard, ten Kate, Leo P., Benjamin, C., Kristoffersson, Ulf, Lund University., Kristoffersson, Ulf,   +32 more
core   +1 more source

Mesenchymal Stem Cell-Derived Exosomes Ameliorate Alzheimer’s Disease Pathology and Improve Cognitive Deficits

Biomedicines, 2021
The accumulation of extracellular β-amyloid (Aβ) plaques within the brain is unique to Alzheimer’s disease (AD) and thought to induce synaptic deficits and neuronal loss. Optimal therapies should tackle the core AD pathophysiology and prevent the decline
Yi-An Chen, Cheng-Hsiu Lu, Chien-Chih Ke, Sain-Jhih Chiu, Fong-Shya Jeng, Chi-Wei Chang, Bang-Hung Yang, Ren-Shyan Liu   +7 more
doaj   +1 more source

The MyoD1 Promoted Muscle Differentiation and Generation by Activating CCND2 in Guanling Cattle

Animals, 2022
The purpose of this study was to analyze the transcriptome of MyoD1 gene knockout MDBK cells (bovine kidney cells) using high-throughput sequencing.
Di Zhou, Yan Wang, Rong Yang, Fu Wang, Zhonghai Zhao, Xin Wang, Lingling Xie, Xingzhou Tian, Guoze Wang, Bo Li, Yu Gong   +10 more
doaj   +1 more source

Cardiovascular safety of Janus kinase inhibitors in patients with rheumatoid arthritis: systematic review and network meta-analysis

Frontiers in Pharmacology, 2023
Background: Janus kinase (JAK) inhibitors have emerged as a progressively utilized therapeutic approach for the management of rheumatoid arthritis (RA). However, the complete determination of their cardiovascular safety remains inconclusive.
Qige Wei, Qige Wei, Qige Wei, Hui Wang, Hui Wang, Hui Wang, Jianglin Zhao, Jianglin Zhao, Jianglin Zhao, Zhongping Luo, Zhongping Luo, Zhongping Luo, Chufeng Wang, Chufeng Wang, Chufeng Wang, Chunmei Zhu, Chunmei Zhu, Chunmei Zhu, Na Su, Shengzhao Zhang, Shengzhao Zhang, Shengzhao Zhang   +21 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source