Results 11 to 20 of about 5,531,670 (305)

Genetic Testing and Genetic Screening [PDF]

Kennedy Institute of Ethics Journal, 1993
In recent years there has been an enormous expansion in the knowledge that may be gleaned from the testing of an individual's genetic material to predict present or future disability or disease either for oneself or one's offspring. The Human Genome Project, which is currently mapping the entire human gene system, is identifying progressively more ...
openaire   +2 more sources

A signal-enhanced lateral flow strip biosensor for ultrasensitive and on-site detection of bisphenol A

Food and Agricultural Immunology, 2018
A signal-enhanced lateral flow strip biosensor has been constructed for ultrasensitive and on-site visual detection of bisphenol A (BPA). The signal amplification principle is based on the capacity of binding a large number of antibody-assembled gold ...
Xiayu Peng, Lichao Kang, Fangqin Pang, Hongmin Li, Ruifeng Luo, Xiaoling Luo, Fengxia Sun   +6 more
doaj   +1 more source

A very early diagnosis of Alstrӧm syndrome by next generation sequencing

BMC Medical Genetics, 2020
Background Alström syndrome is a rare recessively inherited disorder caused by variants in the ALMS1 gene. It is characterized by multiple organ dysfunction, including cone-rod retinal dystrophy, dilated cardiomyopathy, hearing loss, obesity, insulin ...
Leonardo Gatticchi, Jan Miertus, Paolo Enrico Maltese, Simone Bressan, Luca De Antoni, Ludmila Podracká, Lucia Piteková, Vanda Rísová, Mari Mällo, Kaie Jaakson, Kairit Joost, Leonardo Colombo, Matteo Bertelli   +12 more
doaj   +1 more source

Current practice in diagnostic genetic testing of the epilepsies [PDF]

, 2022
Epilepsy genetics is a rapidly developing field, in which novel disease-associated genes, novel mechanisms associated with epilepsy, and precision medicine approaches are continuously being identified.
Berkovic, Samuel F, Weber, Yvonne, Hildebrand, Michael S., Sisodiya, Sanjay M., Helbig, Ingo, Sisodiya, Sanjay M, Platzer, Konrad, Wilmshurst, Jo M., Wilmshurst, Jo M, Berkovic, Samuel F., Hildebrand, Michael S, Lowenstein, Daniel, Weckhuysen, Sarah, Poduri, Annapurna, Lemke, Johannes R., Krey, Ilona, Esterhuizen, Alina, Lerche, Holger, Møller, Rikke S, Lemke, Johannes R, Moller, Rikke S., Sadleir, Lynette, Annapurna Poduri, Yvonne Weber, Caglayan, Hande, Sarah Weckhuysen, Møller, Rikke S.; id_orcid, Tan, Nigel, Ingo Helbig, Mefford, Heathea, Daniel Lowenstein, Mefford, Heathea C., Cross, J. Helen, Møller, Rikke S., Tan, Nigel C. K., Berkovic, Samuel, Konrad Platzer, Johannes R. Lemke, Perucca, Piero, Wilmshurst, Jo, Møller, Rikke, Helbig, Katherine, Sisodiya, Sanjay, Lemke, Johannes, Michael S. Hildebrand, Holger Lerche, Cross, J, Samuel F. Berkovic, Jo M. Wilmshurst, Alina Esterhuizen, Hildebrand, Michael, Ilona Krey, Rikke S. Møller, Lynette Sadleir, Singh, Gagandeep, Sanjay M. Sisodiya   +55 more
core   +1 more source

Intelligent Electrochemical Point-of-Care Test Method with Interface Control Based on DNA Pyramids: Aflatoxin B1 Detection in Food and the Environment

Foods, 2023
Sensitive, intelligent point-of-care test (iPOCT) methods for small molecules like aflatoxin B1 (AFB1) are urgently needed for food and the environment. The challenge remains of surface control in iPOCT.
Wenqin Wu, Yizhen Bai, Tiantian Zhao, Meijuan Liang, Xiaofeng Hu, Du Wang, Xiaoqian Tang, Li Yu, Qi Zhang, Peiwu Li, Zhaowei Zhang   +10 more
doaj   +1 more source

Testing the Children: Do Non-Genetic Health-Care Providers Differ in Their Decision to Advise Genetic Presymptomatic Testing on Minors? A Cross-Sectional Study in Five Countries in the European Union [PDF]

, 2009
BACKGROUND: Within Europe many guidelines exist regarding the genetic testing of minors. Predictive and presymptomatic genetic testing of minors is recommended for disorders for which medical intervention/preventive measures exist, and for which early ...
Schmidtke, Joerg, Baars, Marieke J.H., Julian-Reynier, Claire, Cornel, Martina C., Harris, Rodney, Anionwu, Elizabeth N., Benjamin, Caroline, Schmidtke, Jörg, Harris, Hillary, Plass, Anne Marie C., Baars, Marieke J. H., Challen, Kirsty, Nippert, Irmgard, ten Kate, Leo P., Kristoffersson, Ulf, Lund University., Kristoffersson, Ulf,   +16 more
core   +1 more source

Mesenchymal Stem Cell-Derived Exosomes Ameliorate Alzheimer’s Disease Pathology and Improve Cognitive Deficits

Biomedicines, 2021
The accumulation of extracellular β-amyloid (Aβ) plaques within the brain is unique to Alzheimer’s disease (AD) and thought to induce synaptic deficits and neuronal loss. Optimal therapies should tackle the core AD pathophysiology and prevent the decline
Yi-An Chen, Cheng-Hsiu Lu, Chien-Chih Ke, Sain-Jhih Chiu, Fong-Shya Jeng, Chi-Wei Chang, Bang-Hung Yang, Ren-Shyan Liu   +7 more
doaj   +1 more source

The MyoD1 Promoted Muscle Differentiation and Generation by Activating CCND2 in Guanling Cattle

Animals, 2022
The purpose of this study was to analyze the transcriptome of MyoD1 gene knockout MDBK cells (bovine kidney cells) using high-throughput sequencing.
Di Zhou, Yan Wang, Rong Yang, Fu Wang, Zhonghai Zhao, Xin Wang, Lingling Xie, Xingzhou Tian, Guoze Wang, Bo Li, Yu Gong   +10 more
doaj   +1 more source

Cardiovascular safety of Janus kinase inhibitors in patients with rheumatoid arthritis: systematic review and network meta-analysis

Frontiers in Pharmacology, 2023
Background: Janus kinase (JAK) inhibitors have emerged as a progressively utilized therapeutic approach for the management of rheumatoid arthritis (RA). However, the complete determination of their cardiovascular safety remains inconclusive.
Qige Wei, Qige Wei, Qige Wei, Hui Wang, Hui Wang, Hui Wang, Jianglin Zhao, Jianglin Zhao, Jianglin Zhao, Zhongping Luo, Zhongping Luo, Zhongping Luo, Chufeng Wang, Chufeng Wang, Chufeng Wang, Chunmei Zhu, Chunmei Zhu, Chunmei Zhu, Na Su, Shengzhao Zhang, Shengzhao Zhang, Shengzhao Zhang   +21 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source