Results 231 to 240 of about 17,080,653 (424)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Gene-environment interaction in hereditary nonpolyposis colorectal cancer with implications for diagnosis and genetic testing [PDF]

, 1999
Jae-Gahb Park, Young Jin Park, Juul Wijnen, Hans F. A. Vasen   +3 more
openalex   +1 more source

To (genetic) test or not to test, that is the question [PDF]

Journal of Comparative Effectiveness Research, 2015
openaire   +3 more sources

ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes

American Journal of Gastroenterology, 2015
S. Syngal, R. Brand, J. Church, F. Giardiello, H. Hampel, R. Burt   +5 more
semanticscholar   +1 more source

From Genetic Testing to Precision Medicine in Epilepsy

Neurotherapeutics, 2020
P. Striano, B. Minassian
semanticscholar   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Choosing Progeny-Tested Holstein Sires That Meet Genetic Goals at Minimum Semen Cost

, 1979
R.D. Shanks, A.E. Freeman
openalex   +1 more source

Clinical implications of BRCA1 genetic testing [PDF]

, 1998
Anne Dørum, Ketil Heimdal, Pål Møller
openalex   +1 more source

Pervasive genetic testing

The Lancet, 2018
Thiruchelvam, P, Fisher, C, Leff, DR, Domcheck, S   +3 more
openaire   +5 more sources

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source