Results 41 to 50 of about 1,972,073 (332)

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Genome wide identification of novel DNA methylation driven prognostic markers in colorectal cancer

Scientific Reports
Colorectal cancer (CRC) stands as a major contributor to cancer-related fatalities within China. There is an urgent need to identify accurate biomarkers for recurrence predicting in CRC.
Yuhua Ma, Yuanxin Li, Zhahong Wen, Yining Lai, Kulaixijiang Kamila, Jing Gao, Wang-yang Xu, Chengxiang Gong, Feifan Chen, Liuqing Shi, Yunzhi Zhang, Hanzhang Chen, Min Zhu   +12 more
doaj   +1 more source

Genetic testing of children for adult-onset conditions: opinions of the British adult population and implications for clinical practice

, 2014
This study set out to explore the attitudes of a representative sample of the British public towards genetic testing in children to predict disease in the future. We sought opinions about genetic testing for adult-onset conditions for which no prevention/
A Clarke, A Jolly, Angela Fenwick, Anneke M Lucassen, BA Bernhardt, D Craufurd, DC Wertzdagger, E Campbell, FS Collins, G Eysenbach, GJ Meissen, I Balfour-Lynn, JC Sapp, JM Taber, L Henneman, ME Fallat, O Järvinen, O Järvinen, P Borry, P Borry, P Borry, R Rhodes, RE Duncan, S Dalby, S Robertson, S Shkedi-Rafid, Sandi Dheensa, Shiri Shkedi-Rafid   +27 more
core   +1 more source

Genomics knowledge and attitudes among European public health professionals. Results of a cross-sectional survey [PDF]

, 2020
Background The international public health (PH) community is debating the opportunity to incorporate genomic technologies into PH practice. A survey was conducted to assess attitudes of the European Public Health Association (EUPHA) members towards their
Baccolini, V., Barnhoorn, F., D'Andrea, E., de Vito, C., Marco, M. D., Marzuillo, C., Paget, D. Z., Pitini, E., Rosso, A., Unim, B., Villari, P.   +10 more
core   +2 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Conservative management of giant retroperitoneal hematoma after cesarean section in severe preeclampsia: a rare case report

BMC Pregnancy and Childbirth
Background Spontaneous retroperitoneal hematoma (RPH) after cesarean section is an extremely rare disease with various causes, which can lead to unexplained maternal shock and death. Because cases of RPH are extremely rare in obstetric settings, there is
Jingwen Yu, Mengge Ke, Guangming Wang
doaj   +1 more source

Autoinflammatory Reaction in Dogs Treated for Cancer via G6PD Inhibition

Case Reports in Veterinary Medicine, 2017
Glucose-6-phosphate dehydrogenase (G6PD) is an oncoprotein that is overexpressed in cancer cells to provide the NADPH required for their increased anabolism. NADPH, sourced from G6PD fuels nucleotide biosynthesis, maintains redox potential of thioredoxin
Jonathan W. Nyce
doaj   +1 more source

Epidemiology and Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae and Subsequent MALDI-TOF MS as a Tool to Cluster KPC-2-Producing Klebsiella Pneumoniae, a Retrospective Study

Frontiers in Cellular and Infection Microbiology, 2020
Background: Carbapenem-resistant Klebsiella pneumoniae (CRKP) appeared recently and now presents a particularly critical problem to hospitalized patients worldwide.
Lili Fang, Lili Fang, Lili Fang, Heping Xu, Heping Xu, Heping Xu, Xiaoying Ren, Xiaoying Ren, Xiaoying Ren, Xun Li, Xun Li, Xun Li, Xiaobo Ma, Xiaobo Ma, Xiaobo Ma, Haijian Zhou, Haijian Zhou, Guolin Hong, Guolin Hong, Guolin Hong, Xianming Liang, Xianming Liang   +21 more
doaj   +1 more source

Statistical Inference for Genetic Relatedness Based on High-Dimensional Logistic Regression [PDF]

arXiv, 2022
This paper studies the problem of statistical inference for genetic relatedness between binary traits based on individual-level genome-wide association data. Specifically, under the high-dimensional logistic regression models, we define parameters characterizing the cross-trait genetic correlation, the genetic covariance and the trait-specific genetic ...
arxiv  

Texas Physicians\u27 Awareness and Utilization of Genetic Services [PDF]

, 2015
The number of disorders for which genetic testing is available has increased nearly 500% in the past 15 years. Access to the majority of genetic tests and services hinges on physicians’ ability to identify patients at risk for genetic disease and provide
Jenevein, Callie L
core   +1 more source