Results 211 to 220 of about 8,660,824 (403)

Genetic Therapy of Fuchs Endothelial Corneal Dystrophy: Where Are We? A Review. [PDF]

Genes (Basel)
Stunf Pukl S.
europepmc   +1 more source

Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer.

Cancer Discovery, 2018
Y. Janjigian, F. Sánchez-Vega, P. Jonsson, Walid K. Chatila, J. Hechtman, G. Ku, J. Riches, Yaelle Tuvy, Ritika Kundra, N. Bouvier, E. Vakiani, Jianjiong Gao, Zachary J. Heins, Benjamin E. Gross, D. Kelsen, Liying Zhang, V. Strong, M. Schattner, H. Gerdes, D. Coit, M. Bains, Z. Stadler, V. Rusch, David R. Jones, D. Molena, J. Shia, M. Robson, M. Capanu, S. Middha, A. Zehir, D. Hyman, M. Scaltriti, M. Ladanyi, N. Rosen, D. Ilson, M. Berger, Laura H. Tang, B. Taylor, D. Solit, N. Schultz   +39 more
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

In utero genetic therapy: Treatment of early onset neurological disorders before they start. [PDF]

Mol Ther
Borges B, Brown SM, MacKenzie TC, Sumner CJ.   +3 more
europepmc   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Generation and Treatment of a Novel Severe Model of Visceral Gaucher Disease by Genetic Therapy. [PDF]

Pharmaceutics
Geard AF, Massaro G, Hughes MP, Arbuthnot P, Waddington SN, Rahim AA.   +5 more
europepmc   +1 more source

New Subtypes and Genetic Recombination in HIV Type 1-Infecting Patients with Highly Active Antiretroviral Therapy in Peru (2008–2010)

, 2012
Carlos Augusto Yabar, Maribel Acuña, Cecilia Gazzo, Gabriela Salinas, Fanny Cárdenas, Ada Valverde, Soledad Romero   +6 more
openalex   +2 more sources

Clinical symptoms, underlying pathogenesis, and the prospect of tailored therapies have all benefited from genetic discoveries in Parkinson's disease

, 2020
Moataz Dowaidar
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Topical miRNA Delivery via Elastic Liposomal Formulation: A Promising Genetic Therapy for Cutaneous Lupus Erythematosus (CLE). [PDF]

Int J Mol Sci
Joseph-Mullol B, Royo M, Preat V, Moliné T, Ferrer B, Aparicio G, Cortés-Hernández J, Solé C.   +7 more
europepmc   +1 more source