Results 221 to 230 of about 8,605,496 (403)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Corrigendum: Regulatory Framework for Advanced Therapy Medicinal Products in Europe and United States

Frontiers in Pharmacology, 2020
Carolina Iglesias-Lopez, Antonia Agustí, Antonia Agustí, Mercè Obach, Antonio Vallano, Antonio Vallano   +5 more
doaj   +1 more source

Topical miRNA Delivery via Elastic Liposomal Formulation: A Promising Genetic Therapy for Cutaneous Lupus Erythematosus (CLE). [PDF]

Int J Mol Sci
Joseph-Mullol B, Royo M, Preat V, Moliné T, Ferrer B, Aparicio G, Cortés-Hernández J, Solé C.   +7 more
europepmc   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Bridging therapy-induced phenotypes and genetic immune dysregulation to study interleukin-2-induced immunotoxicology

Sommer, Charline, Jacob, Sophie, Bargmann, Tonia, Shoaib, Muhammad, Alshaikhdeeb, Basel, Satagopam, Venkata Pardhasaradhi, Dehmel, Susann, Neuhaus Vanessa, Braun, Armin, Sewald Katherina, Unav   +10 more
openalex   +1 more source

The Genetic Polymorphism of TNF-α Associated with the Anti-TNF-α Therapy Used for COVID-19 Patients – Another Possible Approach

, 2022
Luciano Barreto Silva, Guilherme Marinho Sampaio, Rodolfo Scavuzzi Carneiro Cunha, Caroline Isabele Félix Muniz, Alexandrino Pereira dos Santos Neto, Hemanuelly Albuquerque dos Anjos, Felipe Leonardo de Melo Almeida Fonseca, Ailton Coelho de Ataíde Filho   +7 more
openalex   +2 more sources

Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer.

Cancer Discovery, 2018
Y. Janjigian, F. Sánchez-Vega, P. Jonsson, Walid K. Chatila, J. Hechtman, G. Ku, J. Riches, Yaelle Tuvy, Ritika Kundra, N. Bouvier, E. Vakiani, Jianjiong Gao, Zachary J. Heins, Benjamin E. Gross, D. Kelsen, Liying Zhang, V. Strong, M. Schattner, H. Gerdes, D. Coit, M. Bains, Z. Stadler, V. Rusch, David R. Jones, D. Molena, J. Shia, M. Robson, M. Capanu, S. Middha, A. Zehir, D. Hyman, M. Scaltriti, M. Ladanyi, N. Rosen, D. Ilson, M. Berger, Laura H. Tang, B. Taylor, D. Solit, N. Schultz   +39 more
semanticscholar   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Surgical therapy and next-generation sequencing-based genetic alteration analysis of malignant solitary fibrous tumor of the pleura

, 2018
Zuoqing Song, Fan Yang, Yingguo Zhang, Ping Fan, Guowei Liu, Chao Li, Wansheng Ding, Yulong Zhang, Xiaohong Xu, Yancheng Ye   +9 more
openalex   +2 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source