Results 241 to 250 of about 8,660,824 (403)

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Gene, genetics and genetic medicines in gastroenterology: Current status and its future. [PDF]

World J Gastroenterol
Kumar A, Sarangi Y, Kaw P.
europepmc   +1 more source

Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy.

Cancer Cell, 2014
Jens G. Lohr, P. Stojanov, S. Carter, Peter Cruz-Gordillo, M. Lawrence, D. Auclair, C. Sougnez, B. Knoechel, Joshua Gould, G. Saksena, K. Cibulskis, A. McKenna, M. Chapman, R. Straussman, J. Levy, L. Perkins, J. Keats, S. Schumacher, Mara W Rosenberg, G. Getz, T. Golub   +20 more
semanticscholar   +1 more source

The New Genetics: Facts, Fictions and Fears [PDF]

, 1995
Sutton, Agneta
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Genetically modified T cells in cancer therapy: opportunities and challenges

, 2015
Michaela Sharpe, Natalie Mount
openalex   +1 more source

In prenatal stem cell transplantation and in utero gene therapy, a wide spectrum of genetic diseases can be diagnosed and treated before birth

, 2021
Moataz Dowaidar
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Male Breast Cancer in Serbia: A 33-Year Retrospective Cohort Study of Genetic Predisposition, Clinicopathological Features, and Survival Outcomes. [PDF]

Cancers (Basel)
Inić Z, Žegarac M, Krivokuća A, Živković O, Buta M, Vučić N, Stević D, Milićević A, Marković I, Đurišić I.   +9 more
europepmc   +1 more source

No Relationship Between TNF-α Genetic Variants and Combination Antiretroviral Therapy-Related Lipodystrophy Syndrome in HIV Type 1-Infected Patients: A Case-Control Study and a Meta-Analysis

, 2010
Sergi Veloso, Montserrat Olona, Joaquim Peraire, Consuelo Viladés, Pedro Pardo, Peré Domingo, Víctor Asensi, Montserrat Broch, Carmen Aguilar, Miguel López-Dupla, Gerard Aragonès, Graciano García‐Pardo, Joan-Josep Sirvent, Joan Vendrell, Cristóbal Richart, Francesc Vidal   +15 more
openalex   +2 more sources