Results 291 to 300 of about 8,605,496 (403)

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

Toward Precision Medicine: Gene Therapy Applications in the Management of Uveal Melanoma. [PDF]

Cancer Rep (Hoboken)
Azani A, Ghassemifar V, Mehrdad Z, Saberivand M, Bagheripour A, Tahmasebi S, Gharedaghi H, Sharafi M, Foroozand H, Soleimani Meigoli MS, Pourali S, Salmaninejad A, Ahmadi Beni F, Behfar Q.   +13 more
europepmc   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

A case and review of fibroblast growth factor-23-mediated hypophosphatemic osteomalacia in the absence of pathogenic <i>PHEX</i> variants. [PDF]

JBMR Plus
Park YA, Gong JY, Chiang C, Trainer AH, Yates CJ.   +4 more
europepmc   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Resolution of chronic idiopathic urticaria with setmelanotide in a patient with Bardet-Biedl Syndrome: A case report. [PDF]

Obes Pillars
Haggerty K, Black J, Abeles R.
europepmc   +1 more source

Genome-wide burden analysis reveals novel genetic determinants of survival in patients with metastatic prostate cancer receiving androgen-targeted therapies: Results from the Million Veterans Program

Tyler J. Nelson, Hannah Carter, Brent S. Rose, Rana R. McKay, Jason L. Vassy, Kathryn M. Pridgen, Richard L. Hauger, Julie A. Lynch, Craig C. Teerlink   +8 more
openalex   +1 more source

Study of genetic polymorphisms of adenosine triphosphate-binding cassette B1 (ABCB1) gene in Iraqi nephrotic syndrome patients on prednisolone therapy [PDF]

Rawan Azad Mohammed, Ahmed Salih Sahib, Qahtan Mohammed Ali   +2 more
openalex   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

How far have we come? From understanding collagen disorders to advancing treatment strategies. [PDF]

Gene Ther
Williamson J, Chong YY, Hung WK, Jacków-Malinowska J.   +3 more
europepmc   +1 more source