Results 301 to 310 of about 8,605,496 (403)

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Clinical and genetic predictors of persistent chemotherapy-induced alopecia despite scalp cooling in breast cancer. [PDF]

NPJ Breast Cancer
Lee H, Kim N, Kim S, Kim JY, Park YH, Ahn HK, Cho J, Kang D, Ahn JS.   +8 more
europepmc   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

A New Targeted Therapy Strategy for Lymphoma. [PDF]

MedComm (2020)
Gale RP.
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Integrating genetic insights into pain management and opioid use optimization in chronic pain and substance abuse populations. [PDF]

Explor Res Clin Soc Pharm
Jairoun AA, Al-Hemyari SS, Shahwan M, Al-Ghananeem AM, Alnuaimi GR, Porntaveetus T.   +5 more
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Efficacy and Safety of Pegfilgrastim in Patients With Severe Congenital Neutropenia. [PDF]

EJHaem
Movahedi M, Moradi L, Alizadeh Z, Yazdi MT, Dehbashi S, Shoormasti RS, Maddah M, Razaghian A, Hamidieh AA, Shariat M, Houshmand M, Alirezaee A, Akbari M, Fazlollahi MR, Pourpak Z.   +14 more
europepmc   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Concurrent head and neck paragangliomas and pulmonary carcinoid tumor: A rare clinical entity. [PDF]

Radiol Case Rep
Nisar F, Rhim HJ, Finocchiaro R, Jain V.
europepmc   +1 more source