Results 301 to 310 of about 1,463,301 (359)

Hydrophobicity causes anomalous migration of cystine/glutamate antiporter SLC7A11 in SDS‐PAGE with low acrylamide concentration

FEBS Open Bio, EarlyView.
SLC7A11 frequently migrates faster in SDS‐PAGE. The present study found that the high hydrophobicity of SLC7A11 causes its anomalous migration in SDS‐PAGE with a low concentration of acrylamide gel. Replacing isoleucine with asparagine reduced hydrophobicity and restored its normal migration at 55 kDa, revealing the role of hydrophobicity and gel ...
Nsengiyumva Emmanuel, Qian He, Yixin Kang, Dianbao Zhang, Min Gao, Minglin Wang, Kexin Fan, Jingwen Xiong, Shaobo Wu, Botao Fa, Zhengtao Xiao, Yingfang Niu, Jun Yao, Yilei Zhang   +13 more
wiley   +1 more source

The potential of CRISPR-Cas9 in cardiovascular medicine: a focus on hereditary cardiomyopathies. [PDF]

Ann Med Surg (Lond)
Rasheed S, Jha M, Waheed A, Farooq U, Fatima A, Haq IU, Khan U, Wardak AB, Gul MH.   +8 more
europepmc   +1 more source

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

FEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G. Ferens, Meredith S. Irwin, Laurie Ailles, Scott A. Yuzwa, Claire M. Robinson, Michael Ohh   +9 more
wiley   +1 more source

Diagnosis and Treatment of Neonatal Diabetes Caused by ATP-Channel Mutations: Genetic Insights, Sulfonylurea Therapy, and Future Directions. [PDF]

Children (Basel)
Trada M, Novara C, Moretto M, Burzi E, Tinti D, De Sanctis L.   +5 more
europepmc   +1 more source

Case Report: Pharmacogenomics in clinical practice - a young male with medication-resistant depression and genetic variations in drug-metabolising enzymes. [PDF]

Front Psychiatry
Beer C, Semmler A, Voisey J.
europepmc   +1 more source

Comparing functional and genomic-based precision medicine in blood cancer patients. [PDF]

Hemasphere
Kazianka L, Pichler A, Agreiter C, Rohrbeck J, Kornauth C, Porpaczy E, Sillaber C, Sperr WR, Gleixner KV, Hauswirth A, Jäger U, Valent P, Jonak C, Porkert S, Exner R, Willenbacher W, Wolf D, Neumeister P, Prochazka K, Deutsch A, Greil R, Schmitt C, Ristl R, Mayerhoefer M, Simonitsch-Klupp I, Pemovska T, Staber PB.   +26 more
europepmc   +1 more source

Phase separation participates in the genetic regulation mechanism of hematopoietic stem cells: potential therapeutic methods. [PDF]

Stem Cell Res Ther
Tang X, Wang Y, Xu R.
europepmc   +1 more source

Association between triglyceride-glucose related indicators, genetic risk, and incident breast cancer among postmenopausal women in UK Biobank. [PDF]

BMC Cancer
Li Z, Zhao Z, Zhang T, Yang X, Chen H, Yin X, Bai H, Liu X, Chang T, Zhang Y, Lu M.   +10 more
europepmc   +1 more source

cMyBP-C in hypertrophic cardiomyopathy: gene therapy and small-molecule innovations. [PDF]

Front Cardiovasc Med
Wood PT, Seffrood MM, Colson BA, Stelzer JE.   +3 more
europepmc   +1 more source