Results 41 to 50 of about 7,750,425 (359)

Assessment of the frequency and association with morbidity of DNA markers in multinational administrative divisions based on indigenous population data (based on cardiovascular diseases)

Кардиоваскулярная терапия и профилактика
Information on morbidity is presented in statistical reports for the entire population of multinational subjects of Russia, but population Biobanks contain information on individual peoples.Aim.
E. V. Balanovskaya, A. Yu. Potanina, S. M. Koshel, D. S. Adamov, I. V. Evsyukov, A. L. Borisova, M. S. Pokrovskaya, A. N. Meshkov   +7 more
doaj   +1 more source

2-Deoxyglucose and Newcastle Disease Virus Synergize to Kill Breast Cancer Cells by Inhibition of Glycolysis Pathway Through Glyceraldehyde3-Phosphate Downregulation

Frontiers in Molecular Biosciences, 2019
Targeting cancer cells metabolism is promising strategy in inhibiting cancer cells progression that are known to exhibit increased aerobic glycolysis. We used the glucose analog 2-Deoxyglucose (2-DG) as a competitor molecule of glucose.
Ahmed Majeed Al-Shammari, Amer Hasan Abdullah, Zainab Majid Allami, Nahi Y. Yaseen   +3 more
doaj   +1 more source

Predicting Benefit From Evolocumab Therapy in Patients With Atherosclerotic Disease Using a Genetic Risk Score

Circulation, 2019
Supplemental Digital Content is available in the text. Background: The ability of a genetic risk score to predict risk in established cardiovascular disease and identify individuals who derive greater benefit from PCSK9 (proprotein convertase subtilisin ...
N. Marston, Frederick K. Kamanu, F. Nordio, Yared Gurmu, C. Roselli, P. Sever, T. Pedersen, A. Keech, Huei Wang, Armando Lira Pineda, R. Giugliano, S. Lubitz, P. Ellinor, M. Sabatine, C. Ruff   +14 more
semanticscholar   +1 more source

Advances in cell transplantation therapy and gene therapy in Parkinson's disease

Chinese Journal of Contemporary Neurology and Neurosurgery, 2022
The role of cell transplantation therapy and gene therapy in the treatment of Parkinson's disease (PD) has attracted more and more attention. It has developed from laboratory research tools to clinical products for patients.
XU Bao⁃lei, CHAN Piu
doaj   +1 more source

Identification of Genetic Mutations in Cancer: Challenge and Opportunity in the New Era of Targeted Therapy

Frontiers in Oncology, 2019
The introduction of targeted therapy is the biggest success in the treatment of cancer in the past few decades. However, heterogeneous cancer is characterized by diverse molecular alterations as well as multiple clinical profiles.
Jing Jin, Xu Wu, Jianhua Yin, Mingxing Li, Jing Shen, Jing Li, Yueshui Zhao, Qijie Zhao, JingBo Wu, Q. Wen, C. Cho, T. Yi, Zhangang Xiao, Liping Qu   +13 more
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Antisense Oligonucleotide-based Splice Correction for USH2A-associated Retinal Degeneration Caused by a Frequent Deep-intronic Mutation

Molecular Therapy: Nucleic Acids, 2016
Usher syndrome (USH) is the most common cause of combined deaf-blindness in man. The hearing loss can be partly compensated by providing patients with hearing aids or cochlear implants, but the loss of vision is currently untreatable.
Radulfus WN Slijkerman, Christel Vaché, Margo Dona, Gema García-García, Mireille Claustres, Lisette Hetterschijt, Theo A Peters, Bas P Hartel, Ronald JE Pennings, José M Millan, Elena Aller, Alejandro Garanto, Rob WJ Collin, Hannie Kremer, Anne-Françoise Roux, Erwin Van Wijk   +15 more
doaj   +1 more source

Male Infertility: Genetics, Mechanism, and Therapies [PDF]

BioMed Research International, 2016
The World Health Organization declaimed that infertility is a major global public health issue of the last few decades. Infertility is commonly defined as the failure to conceive after 1 year of unprotected intercourse and is estimated to concern 72.4 million people worldwide with 40.5 million currently seeking medical care.
Coutton, Charles, Fissore, Rafael, Palermo, Gianpiero, Stouffs, Katrien, Touré, Aminata   +4 more
openaire   +3 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source