Results 51 to 60 of about 835,919 (314)
BiologyNeural excitatory/inhibitory (E/I) imbalance plays a pivotal role in the aging process. However, despite its significant impact, the role of E/I imbalance in motor dysfunction and neurodegenerative diseases has not received sufficient attention.
Xuhui Chen +6 more
doaj +1 more source
Retinal Degenerations: Genetics, Mechanisms, and Therapies [PDF]
Journal of Ophthalmology, 2011 The cumulative results from genetic research and treatment protocols tested on cell and animal models have improved our understanding of pathobiology of inherited and degenerative eye diseases, and have lead to the development of a broad range of potential strategies to treat these conditions.
Ian M. MacDonald +2 more
openaire +4 more sources
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
Down syndrome: A curative prospect?
AIMS Neuroscience, 2020 Experimental work regarding corrective actions on chromosomes and genes, and control of gene products is yielding promising results. It opens the way to advances in dealing with the etiological aspects of Down syndrome and may lead to important changes ...
Jean A. Rondal
doaj +1 more source
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
Genetic Hearing Loss and Gene Therapy [PDF]
Genomics & Informatics, 2018 Genetic hearing loss crosses almost all the categories of hearing loss which includes the following: conductive, sensory, and neural; syndromic and nonsyndromic; congenital, progressive, and adult onset; high-frequency, low-frequency, or mixed frequency; mild or profound; and recessive, dominant, or sex-linked.
Nathanial T Carpena, Min Young Lee
openaire +3 more sources
Frontiers in Molecular Biosciences, 2019 Targeting cancer cells metabolism is promising strategy in inhibiting cancer cells progression that are known to exhibit increased aerobic glycolysis. We used the glucose analog 2-Deoxyglucose (2-DG) as a competitor molecule of glucose.
Ahmed Majeed Al-Shammari +3 more
doaj +1 more source
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
FEBS Letters, EarlyView.Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää +2 more
wiley +1 more source
INNOVATIVE TREATMENT TECHNIQUES IN POLYCYSTIC OVARY SYNDROME (PCOS)
Romanian Journal of Oral Rehabilitation, 2023 Polycystic ovary syndrome (PCOS) is a common condition among women in the fertile period and can have a wide range of symptoms including menstrual disorders, infertility, and, excessive hair growth and metabolic problems.
Cristina Raluca Iorga +6 more
doaj
Therapeutic vascularization in regenerative medicine
Stem Cells Translational Medicine, 2020 Therapeutic angiogenesis, that is, the generation of new vessels by delivery of specific factors, is required both for rapid vascularization of tissue‐engineered constructs and to treat ischemic conditions.
Roberto Gianni‐Barrera +7 more
doaj +1 more source