Results 81 to 90 of about 1,003,750 (315)

Targeted therapy of acute myeloid leukemia

, 2015
Advances in the understanding of the genetic underpinnings of acute myeloid leukemia are rapidly being translated into novel treatment strategies.
Jessica K Altman, Ronan Swords, Carneiro, B.A., Francis J Giles, Altman, Jessica K, Platanias, Leonidas C, Platanias, L.C., Gert Ossenkoppele, Kaplan, Jason B, Kaplan, J.B., Leonidas C Platanias, Jason B Kaplan, Swords, R., Benedito A Carneiro, Swords, Ronan, Altman, J.K., Carneiro, Benedito A, Giles, Francis J, Ossenkoppele, Gert, Ossenkoppele, G., Giles, F.J.   +20 more
core   +1 more source

Genetic therapies for neurological diseases

Pharmacological Reviews
Often, gene therapy reviews concentrate upon specific therapeutic modalities-particularly either viral vector-mediated or a nonviral approach. Here, we draw together a comprehensive array of knowledge across the field of genetic therapy for genetic neurological disease.
Ahad A. Rahim, Manju A. Kurian, Haiyan Zhou, Ross Ferguson, Sarah J. Tabrizi, Gabriele Lignani, Kristian Aquilina, Simon N. Waddington   +7 more
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Therapeutic vascularization in regenerative medicine

Stem Cells Translational Medicine, 2020
Therapeutic angiogenesis, that is, the generation of new vessels by delivery of specific factors, is required both for rapid vascularization of tissue‐engineered constructs and to treat ischemic conditions.
Roberto Gianni‐Barrera, Nunzia Di Maggio, Ludovic Melly, Maximilian G. Burger, Edin Mujagic, Lorenz Gürke, Dirk J. Schaefer, Andrea Banfi   +7 more
doaj   +1 more source

Factors associated with different responses to combination antiretroviral therapy in an observational cohort study of HIV-1 infected patients [PDF]

, 2008
The introduction of combination antiretroviral therapy (cART) into clinical practice for the treatment of HIV in 1995-1996 has led to dramatic reductions in mortality and morbidity. Factors linked to a positive response to therapy include a potent and
Bannister, W.P., Bannister, W P
core  

Targeted genetic repair: an emerging approach to genetic therapy [PDF]

Journal of Clinical Investigation, 2003
The last two decades have heralded a remarkable increase in our understanding of the genetic basis of disease and the endogenous mechanisms responsible for the repair of genomic DNA and the processing of RNA. Targeted gene repair is a powerful yet controversial technique developed to direct base changes in chromosomal genes, while RNA repair is an ...
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Identification of a Novel MTM1 Mutation Associated with X-Linked Myotubular Myopathy: Clinical and Molecular Insights for Prenatal Diagnosis

International Journal of Women's Health
Shixin Chen,1,* Bin Liang,1,* Na Lin,1 Mian Pan,2 Li Li2 1Medical Genetic Diagnosis and Therapy Center, Fujian Key Laboratory for Prenatal Diagnosis and Birth Defects, Fujian Maternity and Child Health Hospital, College of Clinical ...
Chen S, Liang B, Lin N, Pan M, Li L
doaj  

Key research breakthroughs in epilepsy of 2024

Chinese Journal of Contemporary Neurology and Neurosurgery
In 2024, the field of epilepsy has achieved a number of far-reaching advancements in basic and clinical research. These advancements cover aspects including the discovery of new targets for epilepsy surgery, the analysis of molecular pathological ...
WANG Qun, SHAO Xiao-qiu
doaj   +1 more source

Assessing Norton and Norton's model of play therapy through a study of a three-year-old's play therapy experience [PDF]

, 1999
Plan BThere are a variety of play therapy models in research literature that predict stages children move through during play therapy. The purpose of this study is to assess one of these stage models.
Lamon, Kelly Elizabeth Christensen
core