Results 151 to 160 of about 1,509,260 (344)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Editorial: Planctomycetes-Verrucomicrobia-Chlamydiae Bacterial Superphylum: New Model Organisms for Evolutionary Cell Biology

Frontiers in Microbiology, 2017
Laura van Niftrik, Damien P. Devos
doaj   +1 more source

Impact of Iron Deficiency on the Growth and Bioelectrical Profile of Different Gut Bacteria

MicrobiologyOpen
Scope: Iron deficiency (ID) is the most common nutritional deficiency worldwide, impacting gut bacteria's metabolism and cellular biochemistry, but its effects on the microbiota‐gut‐brain axis (MGB) are poorly understood.
Elisa Quarta, Marwane Bourqqia‐Ramzi, David Muñoz‐Rodriguez, María Teresa García‐Esteban, Antonio Murciano‐Cespedosa, Álvaro Mateos González, Francisco José Conejero‐Meca, Juan Lombardo‐Hernandez, Jesús Mansilla‐Guardiola, Simona Baroni, Simonetta Geninatti Crich, Stefano Geuna, Luca Munaron, Deborah Chiabrando, Celia Herrera‐Rincon   +14 more
doaj   +1 more source

Assessing the Utility of Genetic Data as a Monitoring Tool: A Case Study of Eastern Red Bats (Chiroptera: Vespertilionidae: Lasiurus borealis)

, 2009
Anne K. McNeeley, Russell, Amy
openalex   +2 more sources

Genetic testing to identify women at risk of venous thromboembolism with contraceptive pills: evidence- or hope-based tool? [PDF]

, 2016
Marc Blondon, Françoise Boehlen, Pierre Fontana, Patrick Petignat   +3 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Application of a replicative targetable vector system for difficult-to-manipulate streptomycetes

Applied Microbiology and Biotechnology
The low frequency of homologous recombination together with poor efficiency in introducing DNA into the cell are the main factors hampering genetic manipulation of some bacterial strains.
Juan Pablo Gomez-Escribano, Alina Zimmermann, Shu-Ning Xia, Meike Döppner, Julia Moschny, Chambers C. Hughes, Yvonne Mast   +6 more
doaj   +1 more source

Development of reverse genetic tools to study Chapare and Machupo viruses. [PDF]

Virology, 2023
Jain S, Shrivastava-Ranjan P, Flint M, Montgomery JM, Spiropoulou CF, Albariño CG.   +5 more
europepmc   +1 more source

Application of Biomarkers in Obese Infertile Women: A Genetic Tool for a Personalized Treatment [PDF]

Charalampos Voros, Kyriakos Bananis, Angeliki Papapanagiotou, Abraham Pouliakis, Konstantina Mavriki, Ioannis Gkaniatsos, Maria Anastasia Daskalaki, Ioannis Prokopakis, Charalampos Τsimpoukelis, Aristotelis-Marios Koulakmanidis, Menelaos Darlas, Sofia Anysiadou, G. Daskalakis, Ekaterini Domali   +13 more
openalex   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source