Results 131 to 140 of about 733,956 (256)

MAGUS: A Shared Tool for the Genetic Community [PDF]

Circulation: Cardiovascular Quality and Outcomes, 2018
Jessica R, Golbus, Brahmajee K, Nallamothu, Rahul C, Deo   +2 more
openaire   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Optogenetic and chemical genetic tools for rapid repositioning of vimentin intermediate filaments. [PDF]

J Cell Biol
Pasolli M, Meiring JCM, Conboy JP, Koenderink GH, Akhmanova A.   +4 more
europepmc   +2 more sources

Genetic tools for transformation of Xyleborus ambrosia beetle fungal symbionts. [PDF]

Fungal Biol Biotechnol
Joseph RA, Masoudi A, Keyhani NO.
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Genetic Tools in the Nakaseomyces clade for Evolutionary Comparisons of Signal Transduction Pathways. [PDF]

Yeast
Abraham M, Iosue CL, Wykoff DD.
europepmc   +1 more source

Development of genetic tools for heterologous protein expression in a pentose-utilizing environmental isolate of Pseudomonas putida. [PDF]

Microb Biotechnol, 2023
Gauttam R, Eng T, Zhao Z, Ul Ain Rana Q, Simmons BA, Yoshikuni Y, Mukhopadhyay A, Singer SW.   +7 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A set of genetic tools for use in <i>Clostridioides difficile</i> and related species. [PDF]

Microbiology (Reading)
Fisher H, de Lussy Kubisa L, Jakhmola A, Walker E, Kirk JA, Oatley P, Chaudhuri RR, Douce GR, Ormsby MJ, Fagan RP.   +9 more
europepmc   +1 more source

Genetic tools for the stable overexpression of circular RNAs. [PDF]

RNA Biol, 2022
Mecozzi N, Nenci A, Vera O, Bok I, Falzone A, DeNicola GM, Karreth FA.   +6 more
europepmc   +1 more source