Results 131 to 140 of about 696,640 (252)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A set of genetic tools for use in <i>Clostridioides difficile</i> and related species. [PDF]

Microbiology (Reading)
Fisher H, de Lussy Kubisa L, Jakhmola A, Walker E, Kirk JA, Oatley P, Chaudhuri RR, Douce GR, Ormsby MJ, Fagan RP.   +9 more
europepmc   +1 more source

Genetic tools for the stable overexpression of circular RNAs. [PDF]

RNA Biol, 2022
Mecozzi N, Nenci A, Vera O, Bok I, Falzone A, DeNicola GM, Karreth FA.   +6 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Uncovering Insights Into the Biology of Mycobacterium tuberculosis Using Genetic Tools. [PDF]

Microbiologyopen
Stamilla A, Recchia D, Stelitano G, Maci L, Marturano MC, De Rossi E, Chiarelli LR, Pasca MR, Degiacomi G.   +8 more
europepmc   +1 more source

Editorial: Advances in genomic and genetic tools, and their applications for understanding embryonic development and human diseases. [PDF]

Front Cell Dev Biol, 2022
Abu-Elmagd M, Assidi M, Alrefaei AF, Rebai A.   +3 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Genetic tool for the transformation of Clostridium bacteria

, 2017
The invention relates to a genetic tool comprising at least two different nucleic acids allowing the transformation, by homologous recombination, of a bacterium of the genus Clostridium, typically of a solventogenic bacterium.
Wasels, François, Ferreira, Nicolas Lopes, Collas, Florent, Lopez Contreras, A.M.   +3 more
openaire   +3 more sources

Understanding the Preferences of Genetic Tools and Extension Services for the Northern Australia Beef Industry. [PDF]

Animals (Basel)
Menchon P, Cosby A, Swain DL, Manning JK.   +3 more
europepmc   +1 more source

Using newly optimized genetic tools to probe Strongyloides sensory behaviors. [PDF]

Mol Biochem Parasitol, 2022
Mendez P, Walsh B, Hallem EA.
europepmc   +1 more source