Results 111 to 120 of about 1,520,984 (293)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Host range and population structure of Xanthomonas citri pv. mangiferaeindicae : [P4-55] [PDF]
, 2010 #Xanthomonas citri# pv. #mangiferaeindicae# (Xcm) is a bacterium attacking two plant species of the anacardiaceae family : mango (#Mangifera indica#) and pepper tree (#Schinus terebinthifolius#), which is a pest frequently found bordering mango orchards.
Deloison, Gabriel +4 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Quantitative genetic tools for brood stock improvement [PDF]
, 2003 Success in aquaculture and fisheries management depends on viable concept, sound management and animals with high genetic potential. In farm animals and plants application of genetic principles and genetiC tools lead to increased production in accordance
Rajkumar, U, Thomas, P C
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An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Applied and Environmental MicrobiologyClostridium ljungdahlii, as a model acetogen strain, represents a novel platform for biotechnological production for CO2 fixation. The genome of C. ljungdahlii harbors two gene loci associated with glycyl radical enzyme-associated microcompartments (GRMs)
Jun-Zhe Zhang +6 more
doaj +1 more source
OPTIMIZING PROJECT TIME-COST-QUALITY BY USING GENETIC ALGORITHMS [PDF]
Project management causes the problem of efficient resource assignment, activity, time constraints and relationships between activities. Traditional scheduling methods like CPM and PERT are incomplete tools to use in practice because they do not consider
Constanta-Nicoleta BODEA +1 more
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The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Improvements and Future Challenges in the Field of Genetically Sensitive Sample Designs [PDF]
Understanding the sources of individual differences beyond social and economic effects has become a research area of growing interest in psychology, sociology, and economics.
Frank M. Spinath
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