Results 101 to 110 of about 566,900 (297)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

GENETIC DIVERSITY ANALYSIS OF MANGABA (Hancornia speciosa Gomes), AN EXOTIC BRAZILIAN TROPICAL SPECIES

Tropical and Subtropical Agroecosystems, 2012
Twenty genotypes from natural population of mangaba located in Itaporanga D’Ajuda (Sergipe state - Brazil) were subjected to analysis using RAPD markers.
Ana Veruska Cruz da Silva, Allívia Rouse Carregosa Rabbani, José Guedes de Sena-Filho, Camila Santos Almeida, Rosana Barroso Feitosa   +4 more
doaj  

Assessment of genetic variability in finger millet (Eleusine coracana L. Gaertn.) [PDF]

, 2020
N Anuradha, Tssk Patro, U Triveni, P. J. Rao   +3 more
openalex  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Impact of fire on the genetic variability of a natural population of Stylosanthes hippocampoides (Fabaceae) in Corrientes, Argentina

Revista de la Facultad de Ciencias Agrarias
Stylosanthes hippocampoides, a native legume forage species, was first studied by our research team in 2016 to assess genetic variability in natural populations in northeastern Argentina.
Julieta Berenice Arcangeli , Graciela Inés Lavia, María Celeste Silvestri   +2 more
doaj   +2 more sources

ASCOCHYTA BLIGHT (Ascochyta syringae) OF LILAC (Syringa vulgaris L.)

Acta Scientiarum Polonorum: Hortorum Cultus, 2016
Lilac (Syringa vulgaris L.) is a popular ornamental woody plant grown for its very decorative flowers and large, dark-green leaves. The leaves remain on the shrubs for a long time.
Tomasz Kosiada
doaj  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Genetic variability study in F2 population of tetraploid dicoccum wheat crosses

, 2018
C. N. Patil, Deepak Koujalagi
openalex   +2 more sources