Results 231 to 240 of about 1,291,194 (313)

Genetic variability of the prion protein gene (PRNP) in thin-tailed and fat-tailed sheep. [PDF]

Open Vet J
Wicaksono A, Haryanto A, Ibrahim A, Suryandari A, Puspita RAA, Purwaningrum M.   +5 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Genetic variability, morphological diversity, and antioxidant potential in gynoecious Coccinia accessions: implications for breeding and biofortification. [PDF]

BMC Plant Biol
Yadav LP, Gangadhara K, Singh AK, Yadav V, Apparao VV, Pawar A, Kumar S, Janani P, Sahil A, Kumar P, Khapte PS, Meena NK, Jinger D, Rane J.   +13 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Genetic variability of <i>HIF1A</i> and response to treatment with cisplatin in combination with pemetrexed or gemcitabine in patients with malignant mesothelioma. [PDF]

Radiol Oncol
Setina M, Setina E, Doljak Z, Goricar K, Dolzan V, Kovac V.   +5 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

<i>Toxoplasma gondii</i> seroprevalence, seroconversion rates and genetic variability in humans from Uruguay. [PDF]

Parasitology
Valentin-Decuadro A, Tana-Hernandez LR, Faral-Tello P, Fresia P, Guirado M, Rodriguez Rey M, Diaz G, Gimenez V, Greising G, Fernandez N, Gesuele JP, Francia ME.   +11 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Genetic variability and phylogenetic analysis of the long control region in human papillomavirus types 18 and 51 from central China. [PDF]

Virol J
Lin Z, Li T, Yang Y, Liu S, Luo P, Wang S, Qin K, Wu Y, Mei B.   +8 more
europepmc   +1 more source