Results 241 to 250 of about 566,900 (297)

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

The Evolution of Genetic Variability at the LRRK2 Locus. [PDF]

Genes (Basel)
Guenther DT, Follett J, Amouri R, Sassi SB, Hentati F, Farrer MJ.   +5 more
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Pharmacogenomics in Solid Tumors: A Comprehensive Review of Genetic Variability and Its Clinical Implications. [PDF]

Cancers (Basel)
Sánchez-Bayona R, Catalán C, Cobos MA, Bergamino M.   +3 more
europepmc   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

M. caprae in northern Italy: a comprehensive analysis through whole-genome sequencing on the genetic variability in bovine herds. [PDF]

Vet Res
Bertasio C, Carta V, Parisio G, Zanoni M, Tamba M, Mazzera L, Scaltriti E, Pacciarini ML, Alborali GL, Polzer D, Nigsch A, Steinparzer R, Boniotti MB.   +12 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Exploring the Genetic Variability of <i>Gmelina arborea</i> Roxb. in Mexico with Molecular Markers to Establish an Efficient Improvement Program. [PDF]

Plants (Basel)
Ortega-Ramírez ME, Magaña-Álvarez A, Pérez-Brito D, Cortés-Velázquez A, Nexticapan-Garcéz Á, Tapia-Tussell R, Martín-Mex R.   +6 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Estimating Genetic Variability and Heritability of Morpho-Agronomic Traits of M5 Cowpea (<i>Vigna unguiculata</i> (L.) Walp) Mutant Lines. [PDF]

Int J Mol Sci
Ramolekwa K, Pholo-Tait M, Parker T, Malambane G, Ngwako S, Lekgari L.   +5 more
europepmc   +1 more source